Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice

Cortical malformations have a variety of causes. Here the authors use transposon mutagenesis to insert mutations into neural stem cells in the developing mouse cortex to screen for new candidate genes for cortical malformation, and validate some targets in human brain tissue.

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Autores principales:	I-Ling Lu, Chien Chen, Chien-Yi Tung, Hsin-Hung Chen, Jia-Ping Pan, Chia-Hsiang Chang, Jia-Shing Cheng, Yi-An Chen, Chun-Hung Wang, Chia-Wei Huang, Yi-Ning Kang, Hsin-Yun Chang, Lei-Li Li, Kai-Ping Chang, Yang-Hsin Shih, Chi-Hung Lin, Shang-Yeong Kwan, Jin-Wu Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c05ccfd211e247a681f50e19151a3d9c
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spelling	oai:doaj.org-article:c05ccfd211e247a681f50e19151a3d9c2021-12-02T16:56:35ZIdentification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice10.1038/s41467-018-04880-82041-1723https://doaj.org/article/c05ccfd211e247a681f50e19151a3d9c2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04880-8https://doaj.org/toc/2041-1723Cortical malformations have a variety of causes. Here the authors use transposon mutagenesis to insert mutations into neural stem cells in the developing mouse cortex to screen for new candidate genes for cortical malformation, and validate some targets in human brain tissue.I-Ling LuChien ChenChien-Yi TungHsin-Hung ChenJia-Ping PanChia-Hsiang ChangJia-Shing ChengYi-An ChenChun-Hung WangChia-Wei HuangYi-Ning KangHsin-Yun ChangLei-Li LiKai-Ping ChangYang-Hsin ShihChi-Hung LinShang-Yeong KwanJin-Wu TsaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q I-Ling Lu Chien Chen Chien-Yi Tung Hsin-Hung Chen Jia-Ping Pan Chia-Hsiang Chang Jia-Shing Cheng Yi-An Chen Chun-Hung Wang Chia-Wei Huang Yi-Ning Kang Hsin-Yun Chang Lei-Li Li Kai-Ping Chang Yang-Hsin Shih Chi-Hung Lin Shang-Yeong Kwan Jin-Wu Tsai Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice
description	Cortical malformations have a variety of causes. Here the authors use transposon mutagenesis to insert mutations into neural stem cells in the developing mouse cortex to screen for new candidate genes for cortical malformation, and validate some targets in human brain tissue.
format	article
author	I-Ling Lu Chien Chen Chien-Yi Tung Hsin-Hung Chen Jia-Ping Pan Chia-Hsiang Chang Jia-Shing Cheng Yi-An Chen Chun-Hung Wang Chia-Wei Huang Yi-Ning Kang Hsin-Yun Chang Lei-Li Li Kai-Ping Chang Yang-Hsin Shih Chi-Hung Lin Shang-Yeong Kwan Jin-Wu Tsai
author_facet	I-Ling Lu Chien Chen Chien-Yi Tung Hsin-Hung Chen Jia-Ping Pan Chia-Hsiang Chang Jia-Shing Cheng Yi-An Chen Chun-Hung Wang Chia-Wei Huang Yi-Ning Kang Hsin-Yun Chang Lei-Li Li Kai-Ping Chang Yang-Hsin Shih Chi-Hung Lin Shang-Yeong Kwan Jin-Wu Tsai
author_sort	I-Ling Lu
title	Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice
title_short	Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice
title_full	Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice
title_fullStr	Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice
title_full_unstemmed	Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice
title_sort	identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c05ccfd211e247a681f50e19151a3d9c
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Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice

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