Targeting the tumor vasculature with engineered cystine-knot miniproteins

Targeting the tumor vasculature with engineered cystine-knot miniproteins

Cystine-knot miniprotein are small, highly stable, disulfide-rich peptides with increasing potential as drugs and tumor imaging agents. Here the authors develop cystine-knot miniproteins targeting the vascular tumor marker EDB, and use them as probes for in vivo tumor vasculature imaging.

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Autores principales: Bonny Gaby Lui, Nadja Salomon, Joycelyn Wüstehube-Lausch, Matin Daneschdar, Hans-Ulrich Schmoldt, Özlem Türeci, Ugur Sahin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/c061d37878214c01aa09489f0ac9d33c
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spelling oai:doaj.org-article:c061d37878214c01aa09489f0ac9d33c2021-12-02T17:31:39ZTargeting the tumor vasculature with engineered cystine-knot miniproteins10.1038/s41467-019-13948-y2041-1723https://doaj.org/article/c061d37878214c01aa09489f0ac9d33c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13948-yhttps://doaj.org/toc/2041-1723Cystine-knot miniprotein are small, highly stable, disulfide-rich peptides with increasing potential as drugs and tumor imaging agents. Here the authors develop cystine-knot miniproteins targeting the vascular tumor marker EDB, and use them as probes for in vivo tumor vasculature imaging.Bonny Gaby LuiNadja SalomonJoycelyn Wüstehube-LauschMatin DaneschdarHans-Ulrich SchmoldtÖzlem TüreciUgur SahinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bonny Gaby Lui
Nadja Salomon
Joycelyn Wüstehube-Lausch
Matin Daneschdar
Hans-Ulrich Schmoldt
Özlem Türeci
Ugur Sahin
Targeting the tumor vasculature with engineered cystine-knot miniproteins
description Cystine-knot miniprotein are small, highly stable, disulfide-rich peptides with increasing potential as drugs and tumor imaging agents. Here the authors develop cystine-knot miniproteins targeting the vascular tumor marker EDB, and use them as probes for in vivo tumor vasculature imaging.
format article
author Bonny Gaby Lui
Nadja Salomon
Joycelyn Wüstehube-Lausch
Matin Daneschdar
Hans-Ulrich Schmoldt
Özlem Türeci
Ugur Sahin
author_facet Bonny Gaby Lui
Nadja Salomon
Joycelyn Wüstehube-Lausch
Matin Daneschdar
Hans-Ulrich Schmoldt
Özlem Türeci
Ugur Sahin
author_sort Bonny Gaby Lui
title Targeting the tumor vasculature with engineered cystine-knot miniproteins
title_short Targeting the tumor vasculature with engineered cystine-knot miniproteins
title_full Targeting the tumor vasculature with engineered cystine-knot miniproteins
title_fullStr Targeting the tumor vasculature with engineered cystine-knot miniproteins
title_full_unstemmed Targeting the tumor vasculature with engineered cystine-knot miniproteins
title_sort targeting the tumor vasculature with engineered cystine-knot miniproteins
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/c061d37878214c01aa09489f0ac9d33c
work_keys_str_mv AT bonnygabylui targetingthetumorvasculaturewithengineeredcystineknotminiproteins
AT nadjasalomon targetingthetumorvasculaturewithengineeredcystineknotminiproteins
AT joycelynwustehubelausch targetingthetumorvasculaturewithengineeredcystineknotminiproteins
AT matindaneschdar targetingthetumorvasculaturewithengineeredcystineknotminiproteins
AT hansulrichschmoldt targetingthetumorvasculaturewithengineeredcystineknotminiproteins
AT ozlemtureci targetingthetumorvasculaturewithengineeredcystineknotminiproteins
AT ugursahin targetingthetumorvasculaturewithengineeredcystineknotminiproteins
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