Role of Integrins in Sperm Activation and Fertilization

In mammals, integrins are heterodimeric transmembrane glycoproteins that represent a large group of cell adhesion receptors involved in cell–cell, cell–extracellular matrix, and cell–pathogen interactions. Integrin receptors are an important part of signalization pathways and have an ability to tran...

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Autores principales:	Veronika Merc, Michaela Frolikova, Katerina Komrskova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	integrins sperm sperm activation oocyte fusion reproduction Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c06407fccf0944abb0d8fafccc03ca98
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spelling	oai:doaj.org-article:c06407fccf0944abb0d8fafccc03ca982021-11-11T17:15:08ZRole of Integrins in Sperm Activation and Fertilization10.3390/ijms2221118091422-00671661-6596https://doaj.org/article/c06407fccf0944abb0d8fafccc03ca982021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11809https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067In mammals, integrins are heterodimeric transmembrane glycoproteins that represent a large group of cell adhesion receptors involved in cell–cell, cell–extracellular matrix, and cell–pathogen interactions. Integrin receptors are an important part of signalization pathways and have an ability to transmit signals into and out of cells and participate in cell activation. In addition to somatic cells, integrins have also been detected on germ cells and are known to play a crucial role in complex gamete-specific physiological events, resulting in sperm-oocyte fusion. The main aim of this review is to summarize the current knowledge on integrins in reproduction and deliver novel perspectives and graphical interpretations presenting integrin subunits localization and their dynamic relocation during sperm maturation in comparison to the oocyte. A significant part of this review is devoted to discussing the existing view of the role of integrins during sperm migration through the female reproductive tract; oviductal reservoir formation; sperm maturation processes ensuing capacitation and the acrosome reaction, and their direct and indirect involvement in gamete membrane adhesion and fusion leading to fertilization.Veronika MercMichaela FrolikovaKaterina KomrskovaMDPI AGarticleintegrinsspermsperm activationoocytefusionreproductionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11809, p 11809 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	integrins sperm sperm activation oocyte fusion reproduction Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	integrins sperm sperm activation oocyte fusion reproduction Biology (General) QH301-705.5 Chemistry QD1-999 Veronika Merc Michaela Frolikova Katerina Komrskova Role of Integrins in Sperm Activation and Fertilization
description	In mammals, integrins are heterodimeric transmembrane glycoproteins that represent a large group of cell adhesion receptors involved in cell–cell, cell–extracellular matrix, and cell–pathogen interactions. Integrin receptors are an important part of signalization pathways and have an ability to transmit signals into and out of cells and participate in cell activation. In addition to somatic cells, integrins have also been detected on germ cells and are known to play a crucial role in complex gamete-specific physiological events, resulting in sperm-oocyte fusion. The main aim of this review is to summarize the current knowledge on integrins in reproduction and deliver novel perspectives and graphical interpretations presenting integrin subunits localization and their dynamic relocation during sperm maturation in comparison to the oocyte. A significant part of this review is devoted to discussing the existing view of the role of integrins during sperm migration through the female reproductive tract; oviductal reservoir formation; sperm maturation processes ensuing capacitation and the acrosome reaction, and their direct and indirect involvement in gamete membrane adhesion and fusion leading to fertilization.
format	article
author	Veronika Merc Michaela Frolikova Katerina Komrskova
author_facet	Veronika Merc Michaela Frolikova Katerina Komrskova
author_sort	Veronika Merc
title	Role of Integrins in Sperm Activation and Fertilization
title_short	Role of Integrins in Sperm Activation and Fertilization
title_full	Role of Integrins in Sperm Activation and Fertilization
title_fullStr	Role of Integrins in Sperm Activation and Fertilization
title_full_unstemmed	Role of Integrins in Sperm Activation and Fertilization
title_sort	role of integrins in sperm activation and fertilization
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c06407fccf0944abb0d8fafccc03ca98
work_keys_str_mv	AT veronikamerc roleofintegrinsinspermactivationandfertilization AT michaelafrolikova roleofintegrinsinspermactivationandfertilization AT katerinakomrskova roleofintegrinsinspermactivationandfertilization
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Role of Integrins in Sperm Activation and Fertilization

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