Atrial fibrillation and left atrial size and function: a Mendelian randomization study

Abstract Atrial fibrillation (AF) patients have enlarged left atria (LA), but prior studies suggested enlarged atria as both cause and consequence of AF. The aim of this study is to investigate the causal association between AF and LA size and function. In the UK Biobank, all individuals with contou...

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Autores principales:	Yordi J. van de Vegte, Joylene E. Siland, Michiel Rienstra, Pim van der Harst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0675abfa1204c47afe6b2b75431d48b
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spelling	oai:doaj.org-article:c0675abfa1204c47afe6b2b75431d48b2021-12-02T16:45:47ZAtrial fibrillation and left atrial size and function: a Mendelian randomization study10.1038/s41598-021-87859-82045-2322https://doaj.org/article/c0675abfa1204c47afe6b2b75431d48b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87859-8https://doaj.org/toc/2045-2322Abstract Atrial fibrillation (AF) patients have enlarged left atria (LA), but prior studies suggested enlarged atria as both cause and consequence of AF. The aim of this study is to investigate the causal association between AF and LA size and function. In the UK Biobank, all individuals with contoured cardiovascular magnetic resonance data were selected. LA maximal volume (LA max), LA minimal volume (LA min), LA stroke volume and LA ejection fraction were measured and indexed to body surface area (BSA). Two-sample Mendelian randomization analyses were performed using 84 of the known genetic variants associated with AF to assess the association with all LA size and function in individuals without prevalent AF. A total of 4274 individuals (mean age 62.0 ± 7.5 years, 53.2% women) were included. Mendelian randomization analyses estimated a causal effect between genetically determined AF and BSA-indexed LA max, LA min, and LA ejection fraction, but not between AF and LA stroke volume. Leave-one-out analyses showed that the causal associations were attenuated after exclusion of rs67249485, located near PITX2 gene. Our results suggest that AF causally increases LA size and decreases LA ejection fraction. The AF risk allele of rs67249485, located near the PITX2 gene, contributes strongly to these associations.Yordi J. van de VegteJoylene E. SilandMichiel RienstraPim van der HarstNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yordi J. van de Vegte Joylene E. Siland Michiel Rienstra Pim van der Harst Atrial fibrillation and left atrial size and function: a Mendelian randomization study
description	Abstract Atrial fibrillation (AF) patients have enlarged left atria (LA), but prior studies suggested enlarged atria as both cause and consequence of AF. The aim of this study is to investigate the causal association between AF and LA size and function. In the UK Biobank, all individuals with contoured cardiovascular magnetic resonance data were selected. LA maximal volume (LA max), LA minimal volume (LA min), LA stroke volume and LA ejection fraction were measured and indexed to body surface area (BSA). Two-sample Mendelian randomization analyses were performed using 84 of the known genetic variants associated with AF to assess the association with all LA size and function in individuals without prevalent AF. A total of 4274 individuals (mean age 62.0 ± 7.5 years, 53.2% women) were included. Mendelian randomization analyses estimated a causal effect between genetically determined AF and BSA-indexed LA max, LA min, and LA ejection fraction, but not between AF and LA stroke volume. Leave-one-out analyses showed that the causal associations were attenuated after exclusion of rs67249485, located near PITX2 gene. Our results suggest that AF causally increases LA size and decreases LA ejection fraction. The AF risk allele of rs67249485, located near the PITX2 gene, contributes strongly to these associations.
format	article
author	Yordi J. van de Vegte Joylene E. Siland Michiel Rienstra Pim van der Harst
author_facet	Yordi J. van de Vegte Joylene E. Siland Michiel Rienstra Pim van der Harst
author_sort	Yordi J. van de Vegte
title	Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_short	Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_full	Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_fullStr	Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_full_unstemmed	Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_sort	atrial fibrillation and left atrial size and function: a mendelian randomization study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0675abfa1204c47afe6b2b75431d48b
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Atrial fibrillation and left atrial size and function: a Mendelian randomization study

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