Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.

<h4>Background</h4>We presented the photoacoustic imaging (PAI) tool and to evaluate whether microcalcifications in breast tissue can be detected on photoacoustic (PA) images.<h4>Methods</h4>We collected 21 cores containing microcalcifications (n = 11, microcalcification grou...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ga Ram Kim, Jeeun Kang, Jin Young Kwak, Jin Ho Chang, Seung Il Kim, Ji Hyun Youk, Hee Jung Moon, Min Jung Kim, Eun-Kyung Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c06b1b15237640f3b8ba6ba1e42494c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c06b1b15237640f3b8ba6ba1e42494c0
record_format	dspace
spelling	oai:doaj.org-article:c06b1b15237640f3b8ba6ba1e42494c02021-11-25T06:03:24ZPhotoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.1932-620310.1371/journal.pone.0105878https://doaj.org/article/c06b1b15237640f3b8ba6ba1e42494c02014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25153128/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We presented the photoacoustic imaging (PAI) tool and to evaluate whether microcalcifications in breast tissue can be detected on photoacoustic (PA) images.<h4>Methods</h4>We collected 21 cores containing microcalcifications (n = 11, microcalcification group) and none (n = 10, control group) in stereotactic or ultrasound (US) guided 8-gauge vacuum-assisted biopsies. Photoacoustic (PA) images were acquired through ex vivo experiments by transmitting laser pulses with two different wavelengths (700 nm and 800 nm). The presence of microcalcifications in PA images were blindly assessed by two radiologists and compared with specimen mammography. A ratio of the signal amplitude occurring at 700 nm to that occurring at 800 nm was calculated for each PA focus and was called the PAI ratio.<h4>Results</h4>Based on the change of PA signal amplitude between 700 nm and 800 nm, 10 out of 11 specimens containing microcalcifications and 8 out of 10 specimens without calcifications were correctly identified on blind review; the sensitivity, specificity, accuracy, positive predictive and negative predictive values of our blind review were 90.91%, 80.0%, 85.71%, 83.33% and 88.89%. The PAI ratio in the microcalcification group was significantly higher than that in the control group (the median PAI ratio, 2.46 versus 1.11, respectively, P = .001). On subgroup analysis in the microcalcification group, neither malignant diagnosis nor the number or size of calcification-foci was proven to contribute to PAI ratios.<h4>Conclusion</h4>Breast microcalcifications generated distinguishable PA signals unlike breast tissue without calcifications. So, PAI, a non-ionizing and non-invasive hybrid imaging technique, can be an alternative in overcoming the limitations of conventional US imaging.Ga Ram KimJeeun KangJin Young KwakJin Ho ChangSeung Il KimJi Hyun YoukHee Jung MoonMin Jung KimEun-Kyung KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105878 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ga Ram Kim Jeeun Kang Jin Young Kwak Jin Ho Chang Seung Il Kim Ji Hyun Youk Hee Jung Moon Min Jung Kim Eun-Kyung Kim Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.
description	<h4>Background</h4>We presented the photoacoustic imaging (PAI) tool and to evaluate whether microcalcifications in breast tissue can be detected on photoacoustic (PA) images.<h4>Methods</h4>We collected 21 cores containing microcalcifications (n = 11, microcalcification group) and none (n = 10, control group) in stereotactic or ultrasound (US) guided 8-gauge vacuum-assisted biopsies. Photoacoustic (PA) images were acquired through ex vivo experiments by transmitting laser pulses with two different wavelengths (700 nm and 800 nm). The presence of microcalcifications in PA images were blindly assessed by two radiologists and compared with specimen mammography. A ratio of the signal amplitude occurring at 700 nm to that occurring at 800 nm was calculated for each PA focus and was called the PAI ratio.<h4>Results</h4>Based on the change of PA signal amplitude between 700 nm and 800 nm, 10 out of 11 specimens containing microcalcifications and 8 out of 10 specimens without calcifications were correctly identified on blind review; the sensitivity, specificity, accuracy, positive predictive and negative predictive values of our blind review were 90.91%, 80.0%, 85.71%, 83.33% and 88.89%. The PAI ratio in the microcalcification group was significantly higher than that in the control group (the median PAI ratio, 2.46 versus 1.11, respectively, P = .001). On subgroup analysis in the microcalcification group, neither malignant diagnosis nor the number or size of calcification-foci was proven to contribute to PAI ratios.<h4>Conclusion</h4>Breast microcalcifications generated distinguishable PA signals unlike breast tissue without calcifications. So, PAI, a non-ionizing and non-invasive hybrid imaging technique, can be an alternative in overcoming the limitations of conventional US imaging.
format	article
author	Ga Ram Kim Jeeun Kang Jin Young Kwak Jin Ho Chang Seung Il Kim Ji Hyun Youk Hee Jung Moon Min Jung Kim Eun-Kyung Kim
author_facet	Ga Ram Kim Jeeun Kang Jin Young Kwak Jin Ho Chang Seung Il Kim Ji Hyun Youk Hee Jung Moon Min Jung Kim Eun-Kyung Kim
author_sort	Ga Ram Kim
title	Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.
title_short	Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.
title_full	Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.
title_fullStr	Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.
title_full_unstemmed	Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.
title_sort	photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c06b1b15237640f3b8ba6ba1e42494c0
work_keys_str_mv	AT garamkim photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens AT jeeunkang photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens AT jinyoungkwak photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens AT jinhochang photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens AT seungilkim photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens AT jihyunyouk photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens AT heejungmoon photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens AT minjungkim photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens AT eunkyungkim photoacousticimagingofbreastmicrocalcificationsapreliminarystudywith8gaugecorebiopsiedbreastspecimens
_version_	1718414245202231296

Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.

Ejemplares similares