Host stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.

Chytridiomycosis, a disease caused by Batrachochytrium dendrobatidis, has contributed to worldwide amphibian population declines; however, the pathogenesis of this disease is still somewhat unclear. Previous studies suggest that infection disrupts cutaneous sodium transport, which leads to hyponatre...

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Autores principales:	John D Peterson, John E Steffen, Laura K Reinert, Paul A Cobine, Arthur Appel, Louise Rollins-Smith, Mary T Mendonça
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0723fe084be49f89147b2bc20c51285
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spelling	oai:doaj.org-article:c0723fe084be49f89147b2bc20c512852021-11-18T07:48:31ZHost stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.1932-620310.1371/journal.pone.0062146https://doaj.org/article/c0723fe084be49f89147b2bc20c512852013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23630628/?tool=EBIhttps://doaj.org/toc/1932-6203Chytridiomycosis, a disease caused by Batrachochytrium dendrobatidis, has contributed to worldwide amphibian population declines; however, the pathogenesis of this disease is still somewhat unclear. Previous studies suggest that infection disrupts cutaneous sodium transport, which leads to hyponatremia and cardiac failure. However, infection is also correlated with unexplained effects on appetite, skin shedding, and white blood cell profiles. Glucocorticoid hormones may be the biochemical connection between these disparate effects, because they regulate ion homeostasis and can also influence appetite, skin shedding, and white blood cells. During a laboratory outbreak of B. dendrobatidis in Australian Green Tree Frogs, Litoria caerulea, we compared frogs showing clinical signs of chytridiomycosis to infected frogs showing no signs of disease and determined that diseased frogs had elevated baseline corticosterone, decreased plasma sodium and potassium, and altered WBC profiles. Diseased frogs also showed evidence of poorer body condition and elevated metabolic rates compared with frogs showing no signs of disease. Prior to displaying signs of disease, we also observed changes in appetite, body mass, and the presence of shed skin associated with infected but not yet diseased frogs. Collectively, these results suggest that elevated baseline corticosterone is associated with chytridiomycosis and correlates with some of the deleterious effects observed during disease development.John D PetersonJohn E SteffenLaura K ReinertPaul A CobineArthur AppelLouise Rollins-SmithMary T MendonçaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62146 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q John D Peterson John E Steffen Laura K Reinert Paul A Cobine Arthur Appel Louise Rollins-Smith Mary T Mendonça Host stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.
description	Chytridiomycosis, a disease caused by Batrachochytrium dendrobatidis, has contributed to worldwide amphibian population declines; however, the pathogenesis of this disease is still somewhat unclear. Previous studies suggest that infection disrupts cutaneous sodium transport, which leads to hyponatremia and cardiac failure. However, infection is also correlated with unexplained effects on appetite, skin shedding, and white blood cell profiles. Glucocorticoid hormones may be the biochemical connection between these disparate effects, because they regulate ion homeostasis and can also influence appetite, skin shedding, and white blood cells. During a laboratory outbreak of B. dendrobatidis in Australian Green Tree Frogs, Litoria caerulea, we compared frogs showing clinical signs of chytridiomycosis to infected frogs showing no signs of disease and determined that diseased frogs had elevated baseline corticosterone, decreased plasma sodium and potassium, and altered WBC profiles. Diseased frogs also showed evidence of poorer body condition and elevated metabolic rates compared with frogs showing no signs of disease. Prior to displaying signs of disease, we also observed changes in appetite, body mass, and the presence of shed skin associated with infected but not yet diseased frogs. Collectively, these results suggest that elevated baseline corticosterone is associated with chytridiomycosis and correlates with some of the deleterious effects observed during disease development.
format	article
author	John D Peterson John E Steffen Laura K Reinert Paul A Cobine Arthur Appel Louise Rollins-Smith Mary T Mendonça
author_facet	John D Peterson John E Steffen Laura K Reinert Paul A Cobine Arthur Appel Louise Rollins-Smith Mary T Mendonça
author_sort	John D Peterson
title	Host stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.
title_short	Host stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.
title_full	Host stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.
title_fullStr	Host stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.
title_full_unstemmed	Host stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.
title_sort	host stress response is important for the pathogenesis of the deadly amphibian disease, chytridiomycosis, in litoria caerulea.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c0723fe084be49f89147b2bc20c51285
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Host stress response is important for the pathogenesis of the deadly amphibian disease, Chytridiomycosis, in Litoria caerulea.

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