Commensal Bacteria: Not Just Innocent Bystanders

ABSTRACT Neisseria gonorrhoeae is quickly becoming untreatable due to its acquisition of resistance to multiple antimicrobials. It is vital that we begin to understand the mechanisms by which this is occurring. The paper by C. E. Rouquette-Loughlin, J. L. Reimche, J. T. Balthazar, V. Dhulipala, et a...

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Autor principal:	Michael A. Apicella
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Neisseria polysaccharea antimicrobial resistance azithromycin gonorrhea horizontal gene transfer hydrophobic efflux pumps Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c0744568053b4d41ab8ec2d340ff9e4b
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spelling	oai:doaj.org-article:c0744568053b4d41ab8ec2d340ff9e4b2021-11-15T15:55:14ZCommensal Bacteria: Not Just Innocent Bystanders10.1128/mBio.02723-182150-7511https://doaj.org/article/c0744568053b4d41ab8ec2d340ff9e4b2019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02723-18https://doaj.org/toc/2150-7511ABSTRACT Neisseria gonorrhoeae is quickly becoming untreatable due to its acquisition of resistance to multiple antimicrobials. It is vital that we begin to understand the mechanisms by which this is occurring. The paper by C. E. Rouquette-Loughlin, J. L. Reimche, J. T. Balthazar, V. Dhulipala, et al. (mBio 9:e02281-18, https://doi.org/10.1128/mBio.02281-18) has shown that horizontal transfer of DNA from a nasopharyngeal commensal, Neisseria polysaccharea, has resulted in multiple sequence changes in the mtr locus that affect both regulatory and structural regions of the MtrCDE pump, resulting in low-level azithromycin resistance. Studies such as this are increasingly important in our understanding of the movement of resistance between species and for devising strategies to overcome such events.Michael A. ApicellaAmerican Society for MicrobiologyarticleNeisseria polysacchareaantimicrobial resistanceazithromycingonorrheahorizontal gene transferhydrophobic efflux pumpsMicrobiologyQR1-502ENmBio, Vol 10, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neisseria polysaccharea antimicrobial resistance azithromycin gonorrhea horizontal gene transfer hydrophobic efflux pumps Microbiology QR1-502
spellingShingle	Neisseria polysaccharea antimicrobial resistance azithromycin gonorrhea horizontal gene transfer hydrophobic efflux pumps Microbiology QR1-502 Michael A. Apicella Commensal Bacteria: Not Just Innocent Bystanders
description	ABSTRACT Neisseria gonorrhoeae is quickly becoming untreatable due to its acquisition of resistance to multiple antimicrobials. It is vital that we begin to understand the mechanisms by which this is occurring. The paper by C. E. Rouquette-Loughlin, J. L. Reimche, J. T. Balthazar, V. Dhulipala, et al. (mBio 9:e02281-18, https://doi.org/10.1128/mBio.02281-18) has shown that horizontal transfer of DNA from a nasopharyngeal commensal, Neisseria polysaccharea, has resulted in multiple sequence changes in the mtr locus that affect both regulatory and structural regions of the MtrCDE pump, resulting in low-level azithromycin resistance. Studies such as this are increasingly important in our understanding of the movement of resistance between species and for devising strategies to overcome such events.
format	article
author	Michael A. Apicella
author_facet	Michael A. Apicella
author_sort	Michael A. Apicella
title	Commensal Bacteria: Not Just Innocent Bystanders
title_short	Commensal Bacteria: Not Just Innocent Bystanders
title_full	Commensal Bacteria: Not Just Innocent Bystanders
title_fullStr	Commensal Bacteria: Not Just Innocent Bystanders
title_full_unstemmed	Commensal Bacteria: Not Just Innocent Bystanders
title_sort	commensal bacteria: not just innocent bystanders
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/c0744568053b4d41ab8ec2d340ff9e4b
work_keys_str_mv	AT michaelaapicella commensalbacterianotjustinnocentbystanders
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Commensal Bacteria: Not Just Innocent Bystanders

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