The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study

Objective: Active neutrophils are important contributors to Alzheimer’s disease (AD) pathology through the formation of capillary stalls that compromise cerebral blood flow (CBF) and through aberrant neutrophil signaling that advances disease progression. The neutrophil to lymphocyte ratio (NLR) is...

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Autores principales:	Jaime Ramos-Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Alzheimer’s disease dementia Framingham FHS neutrophil to lymphocyte ratio NLR Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c077fbd0f5df488fa22ca12e21761bdc
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spelling	oai:doaj.org-article:c077fbd0f5df488fa22ca12e21761bdc2021-12-01T20:21:58ZThe Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study1663-436510.3389/fnagi.2021.773984https://doaj.org/article/c077fbd0f5df488fa22ca12e21761bdc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.773984/fullhttps://doaj.org/toc/1663-4365Objective: Active neutrophils are important contributors to Alzheimer’s disease (AD) pathology through the formation of capillary stalls that compromise cerebral blood flow (CBF) and through aberrant neutrophil signaling that advances disease progression. The neutrophil to lymphocyte ratio (NLR) is a proxy of neutrophil-mediated inflammation, and higher NLR is found in persons diagnosed with clinical AD. The objective of this study was to investigate whether increased NLR in older adults is independently associated with the risk of subsequent dementia.Methods: We examined associations of baseline NLR with incident dementia risk in the community-based Framingham Heart Study (FHS) longitudinal cohorts. The association between NLR and risk of dementia was evaluated using the cumulative incidence function (CIF) and inverse probability-weighted Cox proportional cause-specific hazards regression models, with adjustment for age, sex, body mass index (BMI), systolic and diastolic blood pressure, diabetes, current smoking status, low-density lipoprotein (LDH), high-density lipoprotein (LDL), total cholesterol, triglycerides, and history of cardiovascular disease (CVD). Random forest survival models were used to evaluate the relative predictive value of the model covariates on dementia risk.Results: The final study sample included 1,648 participants with FHS (average age, 69 years; 56% women). During follow-up (median, 5.9 years), we observed 51 cases of incident dementia, of which 41 were AD cases. Results from weighted models suggested that the NLR was independently associated with incident dementia, and it was preceded in predictive value only by age, history of CVD, and blood pressure at baseline.Conclusion: Our study shows that individuals with higher NLR are at a greater risk of subsequent dementia during a 5.9-year follow-up period. Further evaluating the role of neutrophil-mediated inflammation in AD progression may be warranted.Jaime Ramos-CejudoJaime Ramos-CejudoAndrew D. JohnsonAndrew D. JohnsonAlexa BeiserAlexa BeiserAlexa BeiserSudha SeshadriSudha SeshadriSudha SeshadriJoel SalinasJoel SalinasJeffrey S. BergerJeffrey S. BergerJeffrey S. BergerNathanael R. FillmoreNathanael R. FillmoreNhan DoNhan DoChunlei ZhengZanetta KovbasyukBabak A. ArdekaniBabak A. ArdekaniOmonigho M. BubuAnkit ParekhAntonio ConvitAntonio ConvitRebecca A. BetenskyThomas M. WisniewskiThomas M. WisniewskiThomas M. WisniewskiRicardo S. OsorioRicardo S. OsorioFrontiers Media S.A.articleAlzheimer’s diseasedementiaFraminghamFHSneutrophil to lymphocyte ratioNLRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease dementia Framingham FHS neutrophil to lymphocyte ratio NLR Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Alzheimer’s disease dementia Framingham FHS neutrophil to lymphocyte ratio NLR Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jaime Ramos-Cejudo Jaime Ramos-Cejudo Andrew D. Johnson Andrew D. Johnson Alexa Beiser Alexa Beiser Alexa Beiser Sudha Seshadri Sudha Seshadri Sudha Seshadri Joel Salinas Joel Salinas Jeffrey S. Berger Jeffrey S. Berger Jeffrey S. Berger Nathanael R. Fillmore Nathanael R. Fillmore Nhan Do Nhan Do Chunlei Zheng Zanetta Kovbasyuk Babak A. Ardekani Babak A. Ardekani Omonigho M. Bubu Ankit Parekh Antonio Convit Antonio Convit Rebecca A. Betensky Thomas M. Wisniewski Thomas M. Wisniewski Thomas M. Wisniewski Ricardo S. Osorio Ricardo S. Osorio The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study
description	Objective: Active neutrophils are important contributors to Alzheimer’s disease (AD) pathology through the formation of capillary stalls that compromise cerebral blood flow (CBF) and through aberrant neutrophil signaling that advances disease progression. The neutrophil to lymphocyte ratio (NLR) is a proxy of neutrophil-mediated inflammation, and higher NLR is found in persons diagnosed with clinical AD. The objective of this study was to investigate whether increased NLR in older adults is independently associated with the risk of subsequent dementia.Methods: We examined associations of baseline NLR with incident dementia risk in the community-based Framingham Heart Study (FHS) longitudinal cohorts. The association between NLR and risk of dementia was evaluated using the cumulative incidence function (CIF) and inverse probability-weighted Cox proportional cause-specific hazards regression models, with adjustment for age, sex, body mass index (BMI), systolic and diastolic blood pressure, diabetes, current smoking status, low-density lipoprotein (LDH), high-density lipoprotein (LDL), total cholesterol, triglycerides, and history of cardiovascular disease (CVD). Random forest survival models were used to evaluate the relative predictive value of the model covariates on dementia risk.Results: The final study sample included 1,648 participants with FHS (average age, 69 years; 56% women). During follow-up (median, 5.9 years), we observed 51 cases of incident dementia, of which 41 were AD cases. Results from weighted models suggested that the NLR was independently associated with incident dementia, and it was preceded in predictive value only by age, history of CVD, and blood pressure at baseline.Conclusion: Our study shows that individuals with higher NLR are at a greater risk of subsequent dementia during a 5.9-year follow-up period. Further evaluating the role of neutrophil-mediated inflammation in AD progression may be warranted.
format	article
author	Jaime Ramos-Cejudo Jaime Ramos-Cejudo Andrew D. Johnson Andrew D. Johnson Alexa Beiser Alexa Beiser Alexa Beiser Sudha Seshadri Sudha Seshadri Sudha Seshadri Joel Salinas Joel Salinas Jeffrey S. Berger Jeffrey S. Berger Jeffrey S. Berger Nathanael R. Fillmore Nathanael R. Fillmore Nhan Do Nhan Do Chunlei Zheng Zanetta Kovbasyuk Babak A. Ardekani Babak A. Ardekani Omonigho M. Bubu Ankit Parekh Antonio Convit Antonio Convit Rebecca A. Betensky Thomas M. Wisniewski Thomas M. Wisniewski Thomas M. Wisniewski Ricardo S. Osorio Ricardo S. Osorio
author_facet	Jaime Ramos-Cejudo Jaime Ramos-Cejudo Andrew D. Johnson Andrew D. Johnson Alexa Beiser Alexa Beiser Alexa Beiser Sudha Seshadri Sudha Seshadri Sudha Seshadri Joel Salinas Joel Salinas Jeffrey S. Berger Jeffrey S. Berger Jeffrey S. Berger Nathanael R. Fillmore Nathanael R. Fillmore Nhan Do Nhan Do Chunlei Zheng Zanetta Kovbasyuk Babak A. Ardekani Babak A. Ardekani Omonigho M. Bubu Ankit Parekh Antonio Convit Antonio Convit Rebecca A. Betensky Thomas M. Wisniewski Thomas M. Wisniewski Thomas M. Wisniewski Ricardo S. Osorio Ricardo S. Osorio
author_sort	Jaime Ramos-Cejudo
title	The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study
title_short	The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study
title_full	The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study
title_fullStr	The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study
title_full_unstemmed	The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study
title_sort	neutrophil to lymphocyte ratio is associated with the risk of subsequent dementia in the framingham heart study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c077fbd0f5df488fa22ca12e21761bdc
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The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study

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