Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles

ZhongQian Hu,1 JiaLe Qin,2 TianKuan Li,1 JinHe Guo3 1Department of Ultrasound, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu 210009, People’s Republic of China; 2Department of Ultrasound, Women’s Hospital, School of Medicine, Zhejiang University, Hangzh...

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Autores principales:	Hu Z, Qin J, Li T, Guo J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	thyroid tumour SHP2 Gd3+ nanoparticles MR molecular imaging Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c07c7576366644e59903d43373acc08d
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spelling	oai:doaj.org-article:c07c7576366644e59903d43373acc08d2021-12-02T04:07:20ZThyroid cancer MR molecular imaging via SHP2-targeted nanoparticles1178-2013https://doaj.org/article/c07c7576366644e59903d43373acc08d2019-09-01T00:00:00Zhttps://www.dovepress.com/thyroid-cancer-mr-molecular-imaging-via-shp2-targeted-nanoparticles-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013ZhongQian Hu,1 JiaLe Qin,2 TianKuan Li,1 JinHe Guo3 1Department of Ultrasound, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu 210009, People’s Republic of China; 2Department of Ultrasound, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, People’s Republic of China; 3Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu 210009, People’s Republic of ChinaCorrespondence: TianKuan LiDepartment of Ultrasound, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, People’s Republic of ChinaTel +86 25 8327 5402Email ltk1105@126.comJinHe GuoCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, People’s Republic of ChinaTel +86 25 8327 2114Email jinheguo@sina.comBackground: Molecular imaging has generated a great demand to develop targeted contrast agents for MR imaging.Materials and methods: In this study, we synthesized Src homology 2-containing phosphotyrosine phosphatase 2 (SHP2)-targeted and polylactic-co-glycolic acid–-based nanoparticles (NPs), which encapsulated perfluoropentane and being chelated with gadolinium (Gd3+) as an efficient molecular probe for targeting MR imaging on thyroid carcinoma.Results: These NPs displayed practical properties and favorable biocompatibility in vitro. Furthermore, they showed abilities to specifically target thyroid cancer and enhance MRI as a contrast agent in both in vitro and in vivo experiments.Conclusion: This novel MR molecular imaging based on this SHP2-targeted contrast agent provides a useful and non-invasive method for the early detection of thyroid carcinoma.Keywords: thyroid tumor, SHP2, Gd3+, nanoparticles, MR molecular imagingHu ZQin JLi TGuo JDove Medical Pressarticlethyroid tumourSHP2Gd3+nanoparticlesMR molecular imagingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 7365-7373 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid tumour SHP2 Gd3+ nanoparticles MR molecular imaging Medicine (General) R5-920
spellingShingle	thyroid tumour SHP2 Gd3+ nanoparticles MR molecular imaging Medicine (General) R5-920 Hu Z Qin J Li T Guo J Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles
description	ZhongQian Hu,1 JiaLe Qin,2 TianKuan Li,1 JinHe Guo3 1Department of Ultrasound, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu 210009, People’s Republic of China; 2Department of Ultrasound, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, People’s Republic of China; 3Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu 210009, People’s Republic of ChinaCorrespondence: TianKuan LiDepartment of Ultrasound, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, People’s Republic of ChinaTel +86 25 8327 5402Email ltk1105@126.comJinHe GuoCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, People’s Republic of ChinaTel +86 25 8327 2114Email jinheguo@sina.comBackground: Molecular imaging has generated a great demand to develop targeted contrast agents for MR imaging.Materials and methods: In this study, we synthesized Src homology 2-containing phosphotyrosine phosphatase 2 (SHP2)-targeted and polylactic-co-glycolic acid–-based nanoparticles (NPs), which encapsulated perfluoropentane and being chelated with gadolinium (Gd3+) as an efficient molecular probe for targeting MR imaging on thyroid carcinoma.Results: These NPs displayed practical properties and favorable biocompatibility in vitro. Furthermore, they showed abilities to specifically target thyroid cancer and enhance MRI as a contrast agent in both in vitro and in vivo experiments.Conclusion: This novel MR molecular imaging based on this SHP2-targeted contrast agent provides a useful and non-invasive method for the early detection of thyroid carcinoma.Keywords: thyroid tumor, SHP2, Gd3+, nanoparticles, MR molecular imaging
format	article
author	Hu Z Qin J Li T Guo J
author_facet	Hu Z Qin J Li T Guo J
author_sort	Hu Z
title	Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles
title_short	Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles
title_full	Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles
title_fullStr	Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles
title_full_unstemmed	Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles
title_sort	thyroid cancer mr molecular imaging via shp2-targeted nanoparticles
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c07c7576366644e59903d43373acc08d
work_keys_str_mv	AT huz thyroidcancermrmolecularimagingviashp2targetednanoparticles AT qinj thyroidcancermrmolecularimagingviashp2targetednanoparticles AT lit thyroidcancermrmolecularimagingviashp2targetednanoparticles AT guoj thyroidcancermrmolecularimagingviashp2targetednanoparticles
_version_	1718401457353392128

Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles

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