The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.

Influenza A (H3N2) offers a well-studied, yet not fully understood, disease in terms of the interactions between pathogen population dynamics, epidemiology and genetics. A major open question is why the virus population is globally dominated by a single and very recently diverged (2-8 years) lineage...

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Autores principales:	Daniel Zinder, Trevor Bedford, Sunetra Gupta, Mercedes Pascual
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c07cc209a6c74d228d7e3558282763cf
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spelling	oai:doaj.org-article:c07cc209a6c74d228d7e3558282763cf2021-11-18T06:06:11ZThe roles of competition and mutation in shaping antigenic and genetic diversity in influenza.1553-73661553-737410.1371/journal.ppat.1003104https://doaj.org/article/c07cc209a6c74d228d7e3558282763cf2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300455/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Influenza A (H3N2) offers a well-studied, yet not fully understood, disease in terms of the interactions between pathogen population dynamics, epidemiology and genetics. A major open question is why the virus population is globally dominated by a single and very recently diverged (2-8 years) lineage. Classically, this has been modeled by limiting the generation of new successful antigenic variants, such that only a small subset of progeny acquire the necessary mutations to evade host immunity. An alternative approach was recently suggested by Recker et al. in which a limited number of antigenic variants are continuously generated, but most of these are suppressed by pre-existing host population immunity. Here we develop a framework spanning the regimes described above to explore the impact of rates of mutation and levels of competition on phylodynamic patterns. We find that the evolutionary dynamics of the subtype H3N2 influenza is most easily generated within this framework when it is mutation limited as well as being under strong immune selection at a number of epitope regions of limited diversity.Daniel ZinderTrevor BedfordSunetra GuptaMercedes PascualPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 1, p e1003104 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Daniel Zinder Trevor Bedford Sunetra Gupta Mercedes Pascual The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.
description	Influenza A (H3N2) offers a well-studied, yet not fully understood, disease in terms of the interactions between pathogen population dynamics, epidemiology and genetics. A major open question is why the virus population is globally dominated by a single and very recently diverged (2-8 years) lineage. Classically, this has been modeled by limiting the generation of new successful antigenic variants, such that only a small subset of progeny acquire the necessary mutations to evade host immunity. An alternative approach was recently suggested by Recker et al. in which a limited number of antigenic variants are continuously generated, but most of these are suppressed by pre-existing host population immunity. Here we develop a framework spanning the regimes described above to explore the impact of rates of mutation and levels of competition on phylodynamic patterns. We find that the evolutionary dynamics of the subtype H3N2 influenza is most easily generated within this framework when it is mutation limited as well as being under strong immune selection at a number of epitope regions of limited diversity.
format	article
author	Daniel Zinder Trevor Bedford Sunetra Gupta Mercedes Pascual
author_facet	Daniel Zinder Trevor Bedford Sunetra Gupta Mercedes Pascual
author_sort	Daniel Zinder
title	The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.
title_short	The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.
title_full	The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.
title_fullStr	The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.
title_full_unstemmed	The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.
title_sort	roles of competition and mutation in shaping antigenic and genetic diversity in influenza.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c07cc209a6c74d228d7e3558282763cf
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The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.

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