Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
Endoplasmic reticulum (ER) stress has been proposed to play a role in metabolic diseases. Here, Sasako and colleagues identify stromal cell-derived factor 2 like 1 (Sdf2l1) as a regulator of the ER stress response to feeding in the liver, and suggest that its downregulation may promote diabetes and...
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/c07e772286d14098b0891e9657574217 |
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oai:doaj.org-article:c07e772286d14098b0891e96575742172021-12-02T16:57:44ZHepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism10.1038/s41467-019-08591-62041-1723https://doaj.org/article/c07e772286d14098b0891e96575742172019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08591-6https://doaj.org/toc/2041-1723Endoplasmic reticulum (ER) stress has been proposed to play a role in metabolic diseases. Here, Sasako and colleagues identify stromal cell-derived factor 2 like 1 (Sdf2l1) as a regulator of the ER stress response to feeding in the liver, and suggest that its downregulation may promote diabetes and hepatic steatosis in humans.Takayoshi SasakoMitsuru OhsugiNaoto KubotaShinsuke ItohYukiko OkazakiAi TeraiTetsuya KubotaSatoshi YamashitaKunio NakatsukasaTakumi KamuraKaito IwayamaKumpei TokuyamaHiroshi KiyonariYasuhide FurutaJunji ShibaharaMasashi FukayamaKenichiro EnookuKazuya OkushinTakeya TsutsumiRyosuke TateishiKazuyuki TobeHiroshi AsaharaKazuhiko KoikeTakashi KadowakiKohjiro UekiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Takayoshi Sasako Mitsuru Ohsugi Naoto Kubota Shinsuke Itoh Yukiko Okazaki Ai Terai Tetsuya Kubota Satoshi Yamashita Kunio Nakatsukasa Takumi Kamura Kaito Iwayama Kumpei Tokuyama Hiroshi Kiyonari Yasuhide Furuta Junji Shibahara Masashi Fukayama Kenichiro Enooku Kazuya Okushin Takeya Tsutsumi Ryosuke Tateishi Kazuyuki Tobe Hiroshi Asahara Kazuhiko Koike Takashi Kadowaki Kohjiro Ueki Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| description |
Endoplasmic reticulum (ER) stress has been proposed to play a role in metabolic diseases. Here, Sasako and colleagues identify stromal cell-derived factor 2 like 1 (Sdf2l1) as a regulator of the ER stress response to feeding in the liver, and suggest that its downregulation may promote diabetes and hepatic steatosis in humans. |
| format |
article |
| author |
Takayoshi Sasako Mitsuru Ohsugi Naoto Kubota Shinsuke Itoh Yukiko Okazaki Ai Terai Tetsuya Kubota Satoshi Yamashita Kunio Nakatsukasa Takumi Kamura Kaito Iwayama Kumpei Tokuyama Hiroshi Kiyonari Yasuhide Furuta Junji Shibahara Masashi Fukayama Kenichiro Enooku Kazuya Okushin Takeya Tsutsumi Ryosuke Tateishi Kazuyuki Tobe Hiroshi Asahara Kazuhiko Koike Takashi Kadowaki Kohjiro Ueki |
| author_facet |
Takayoshi Sasako Mitsuru Ohsugi Naoto Kubota Shinsuke Itoh Yukiko Okazaki Ai Terai Tetsuya Kubota Satoshi Yamashita Kunio Nakatsukasa Takumi Kamura Kaito Iwayama Kumpei Tokuyama Hiroshi Kiyonari Yasuhide Furuta Junji Shibahara Masashi Fukayama Kenichiro Enooku Kazuya Okushin Takeya Tsutsumi Ryosuke Tateishi Kazuyuki Tobe Hiroshi Asahara Kazuhiko Koike Takashi Kadowaki Kohjiro Ueki |
| author_sort |
Takayoshi Sasako |
| title |
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| title_short |
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| title_full |
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| title_fullStr |
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| title_full_unstemmed |
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| title_sort |
hepatic sdf2l1 controls feeding-induced er stress and regulates metabolism |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/c07e772286d14098b0891e9657574217 |
| work_keys_str_mv |
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| _version_ |
1718382469853478912 |