The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases

Edward A Lin1, Chuan-ju Liu1,21Department of Orthopaedic Surgery, 2Department of Cell Biology, New York University School of Medicine, New York, NY, USAAbstract: The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a family of secreted zinc metalloproteinases with a p...

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Autores principales:	Edward A Lin, Chuan-ju Liu
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/c0829421bc7f4c1f97d4a753cfec8e6b
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spelling	oai:doaj.org-article:c0829421bc7f4c1f97d4a753cfec8e6b2021-12-02T00:07:38ZThe emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases1179-156Xhttps://doaj.org/article/c0829421bc7f4c1f97d4a753cfec8e6b2009-09-01T00:00:00Zhttp://www.dovepress.com/the-emerging-roles-of-adamts-7-and-adamts-12-matrix-metalloproteinases-a3569https://doaj.org/toc/1179-156XEdward A Lin1, Chuan-ju Liu1,21Department of Orthopaedic Surgery, 2Department of Cell Biology, New York University School of Medicine, New York, NY, USAAbstract: The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a family of secreted zinc metalloproteinases with a precisely ordered modular organization. These enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregulation has been implicated in disease-related processes such as arthritis, atherosclerosis, cancer, and inflammation. ADAMTS-7 and ADAMTS-12 share a similar domain organization to each other and form a subgroup within the ADAMTS family. Emerging evidence suggests that ADAMTS-7 and ADAMTS-12 may play an important role in the development and pathogenesis of various kinds of diseases. In this review, we summarize what is currently known about the roles of these two metalloproteinases, with a special focus on their involvement in chondrogenesis, endochondral ossification, and the pathogenesis of arthritis, atherosclerosis, and cancer. The future study of ADAMTS-7 and ADAMTS-12, as well as the molecules with which they interact, will help us to better understand a variety of human diseases from both a biological and therapeutic standpoint.Keywords: ADAMTS-7, ADAMTS-12, COMP, GEP, arthritis, chondrogenesis, atherosclerosis Edward A LinChuan-ju LiuDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2009, Iss default, Pp 121-131 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Edward A Lin Chuan-ju Liu The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
description	Edward A Lin1, Chuan-ju Liu1,21Department of Orthopaedic Surgery, 2Department of Cell Biology, New York University School of Medicine, New York, NY, USAAbstract: The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a family of secreted zinc metalloproteinases with a precisely ordered modular organization. These enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregulation has been implicated in disease-related processes such as arthritis, atherosclerosis, cancer, and inflammation. ADAMTS-7 and ADAMTS-12 share a similar domain organization to each other and form a subgroup within the ADAMTS family. Emerging evidence suggests that ADAMTS-7 and ADAMTS-12 may play an important role in the development and pathogenesis of various kinds of diseases. In this review, we summarize what is currently known about the roles of these two metalloproteinases, with a special focus on their involvement in chondrogenesis, endochondral ossification, and the pathogenesis of arthritis, atherosclerosis, and cancer. The future study of ADAMTS-7 and ADAMTS-12, as well as the molecules with which they interact, will help us to better understand a variety of human diseases from both a biological and therapeutic standpoint.Keywords: ADAMTS-7, ADAMTS-12, COMP, GEP, arthritis, chondrogenesis, atherosclerosis
format	article
author	Edward A Lin Chuan-ju Liu
author_facet	Edward A Lin Chuan-ju Liu
author_sort	Edward A Lin
title	The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
title_short	The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
title_full	The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
title_fullStr	The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
title_full_unstemmed	The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
title_sort	emerging roles of adamts-7 and adamts-12 matrix metalloproteinases
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/c0829421bc7f4c1f97d4a753cfec8e6b
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The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases

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