Association Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China

Guangxu Liu,1,2 Jingtao Dou,3,4 Deqiang Zheng,1,2 Jie Zhang,1,2 Meiping Wang,1,2 Wei Li,1,2 Jing Wen,1,2 Juming Lu,3 Linong Ji,5 Yan He1,2 1Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Munic...

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Autores principales:	Liu G, Dou J, Zheng D, Zhang J, Wang M, Li W, Wen J, Lu J, Ji L, He Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	abnormal glycemic phenotype diabetic nephropathy diabetic retinopathy type 2 diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c083ce1eeb23405090dbbcb277e349b4
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spelling	oai:doaj.org-article:c083ce1eeb23405090dbbcb277e349b42021-12-02T11:21:01ZAssociation Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China1178-7007https://doaj.org/article/c083ce1eeb23405090dbbcb277e349b42020-11-01T00:00:00Zhttps://www.dovepress.com/association-between-abnormal-glycemic-phenotypes-and-microvascular-com-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Guangxu Liu,1,2 Jingtao Dou,3,4 Deqiang Zheng,1,2 Jie Zhang,1,2 Meiping Wang,1,2 Wei Li,1,2 Jing Wen,1,2 Juming Lu,3 Linong Ji,5 Yan He1,2 1Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, People’s Republic of China; 3Department of Endocrinology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Endocrinology, Hainan Branch of Chinese PLA General Hospital, Sanya, People’s Republic of China; 5Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yan He; Jingtao Dou Email yanhe1220@126.com; jingtaodou@163.comPurpose: The objective of this study was to investigate the association of abnormal glycemic phenotypes with microvascular complications in type 2 diabetes patients.Participants and Methods: A total of 24,266 participants who were from the multicenter cross-sectional survey of China National HbA1c Surveillance System across China were included in the present study. Diabetes patients with abnormal glucose were divided into three groups according to phenotype: isolated fasting hyperglycemia (IFH), isolated postprandial hyperglycemia (IPH), or combined hyperglycemia (CH). The main outcomes were isolated diabetic retinopathy, isolated diabetic nephropathy, and combined diabetic retinopathy with nephropathy. Multivariate logistic regression was used to assess the association of abnormal glycemic phenotypes with microvascular complications.Results: The CH phenotype had the highest prevalence of isolated diabetic retinopathy, isolated diabetic nephropathy and combined diabetic retinopathy with nephropathy, followed by IPH. Multivariate analysis showed that the CH phenotype was associated with the highest risk of isolated diabetic retinopathy (OR: 1.20, 95% CI: 1.02– 1.41), isolated diabetic nephropathy (OR: 1.59, 95% CI: 1.27– 2.01) and combined diabetic retinopathy with nephropathy (OR: 1.93, 95% CI: 1.44– 2.59). More importantly, participants with IPH phenotype also showed significantly higher risks of isolated diabetic retinopathy (OR: 1.16, 95% CI: 1.05– 1.28), isolated diabetic nephropathy (OR: 1.37, 95% CI: 1.09– 1.37) and combined diabetic retinopathy with nephropathy (OR:1.64, 95% CI: 1.21– 2.21) compared to the IFH phenotype. After stratifying by age, sex, diabetes duration and BMI, the higher risks of isolated diabetic retinopathy, isolated diabetic nephropathy and combined diabetic retinopathy with nephropathy were confirmed in IPH phenotype group, compared to the IFH phenotype group.Conclusion: Diabetic patients with IPH phenotype had higher risks of isolated diabetic retinopathy, isolated diabetic nephropathy and combined diabetic retinopathy with nephropathy compared with the participants phenotype of IFH, but lower than the phenotype of CH.Keywords: abnormal glycemic phenotype, diabetic nephropathy, diabetic retinopathy, type 2 diabetes mellitusLiu GDou JZheng DZhang JWang MLi WWen JLu JJi LHe YDove Medical Pressarticleabnormal glycemic phenotypediabetic nephropathydiabetic retinopathytype 2 diabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4651-4659 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	abnormal glycemic phenotype diabetic nephropathy diabetic retinopathy type 2 diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	abnormal glycemic phenotype diabetic nephropathy diabetic retinopathy type 2 diabetes mellitus Specialties of internal medicine RC581-951 Liu G Dou J Zheng D Zhang J Wang M Li W Wen J Lu J Ji L He Y Association Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China
description	Guangxu Liu,1,2 Jingtao Dou,3,4 Deqiang Zheng,1,2 Jie Zhang,1,2 Meiping Wang,1,2 Wei Li,1,2 Jing Wen,1,2 Juming Lu,3 Linong Ji,5 Yan He1,2 1Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, People’s Republic of China; 3Department of Endocrinology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Endocrinology, Hainan Branch of Chinese PLA General Hospital, Sanya, People’s Republic of China; 5Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yan He; Jingtao Dou Email yanhe1220@126.com; jingtaodou@163.comPurpose: The objective of this study was to investigate the association of abnormal glycemic phenotypes with microvascular complications in type 2 diabetes patients.Participants and Methods: A total of 24,266 participants who were from the multicenter cross-sectional survey of China National HbA1c Surveillance System across China were included in the present study. Diabetes patients with abnormal glucose were divided into three groups according to phenotype: isolated fasting hyperglycemia (IFH), isolated postprandial hyperglycemia (IPH), or combined hyperglycemia (CH). The main outcomes were isolated diabetic retinopathy, isolated diabetic nephropathy, and combined diabetic retinopathy with nephropathy. Multivariate logistic regression was used to assess the association of abnormal glycemic phenotypes with microvascular complications.Results: The CH phenotype had the highest prevalence of isolated diabetic retinopathy, isolated diabetic nephropathy and combined diabetic retinopathy with nephropathy, followed by IPH. Multivariate analysis showed that the CH phenotype was associated with the highest risk of isolated diabetic retinopathy (OR: 1.20, 95% CI: 1.02– 1.41), isolated diabetic nephropathy (OR: 1.59, 95% CI: 1.27– 2.01) and combined diabetic retinopathy with nephropathy (OR: 1.93, 95% CI: 1.44– 2.59). More importantly, participants with IPH phenotype also showed significantly higher risks of isolated diabetic retinopathy (OR: 1.16, 95% CI: 1.05– 1.28), isolated diabetic nephropathy (OR: 1.37, 95% CI: 1.09– 1.37) and combined diabetic retinopathy with nephropathy (OR:1.64, 95% CI: 1.21– 2.21) compared to the IFH phenotype. After stratifying by age, sex, diabetes duration and BMI, the higher risks of isolated diabetic retinopathy, isolated diabetic nephropathy and combined diabetic retinopathy with nephropathy were confirmed in IPH phenotype group, compared to the IFH phenotype group.Conclusion: Diabetic patients with IPH phenotype had higher risks of isolated diabetic retinopathy, isolated diabetic nephropathy and combined diabetic retinopathy with nephropathy compared with the participants phenotype of IFH, but lower than the phenotype of CH.Keywords: abnormal glycemic phenotype, diabetic nephropathy, diabetic retinopathy, type 2 diabetes mellitus
format	article
author	Liu G Dou J Zheng D Zhang J Wang M Li W Wen J Lu J Ji L He Y
author_facet	Liu G Dou J Zheng D Zhang J Wang M Li W Wen J Lu J Ji L He Y
author_sort	Liu G
title	Association Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China
title_short	Association Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China
title_full	Association Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China
title_fullStr	Association Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China
title_full_unstemmed	Association Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China
title_sort	association between abnormal glycemic phenotypes and microvascular complications of type 2 diabetes mellitus outpatients in china
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/c083ce1eeb23405090dbbcb277e349b4
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Association Between Abnormal Glycemic Phenotypes and Microvascular Complications of Type 2 Diabetes Mellitus Outpatients in China

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