The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.

<h4>Background</h4>Previous studies showed the possible association between obesity, dietary pattern, and depressive symptoms. Due to the lack of enough data to confirm the association of obesity and depression in the Middle East, here, we aimed to explore the possible mediatory role of...

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Autores principales:	Leila Setayesh, Reyhane Ebrahimi, Sara Pooyan, Habib Yarizadeh, Elaheh Rashidbeygi, Negin Badrooj, Hossein Imani, Khadijeh Mirzaei
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0857460905d44e69e0e3d3bffd8d1d1
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spelling	oai:doaj.org-article:c0857460905d44e69e0e3d3bffd8d1d12021-12-02T20:14:40ZThe possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.1932-620310.1371/journal.pone.0257275https://doaj.org/article/c0857460905d44e69e0e3d3bffd8d1d12021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257275https://doaj.org/toc/1932-6203<h4>Background</h4>Previous studies showed the possible association between obesity, dietary pattern, and depressive symptoms. Due to the lack of enough data to confirm the association of obesity and depression in the Middle East, here, we aimed to explore the possible mediatory role of adipokines Galectin-3, transforming growth factor-beta (TGF-β), and endothelial plasminogen activator inhibitor (PAI-1) in the association between low carbohydrate diet (LCD) and depressive symptoms.<h4>Methods</h4>A total of 256 women aged 17-56 years old were grouped based on their LCD score. Depression anxiety stress scales-21 (DASS-21) self-administered questionnaire was used to evaluate the three negative emotional states of stress, depressive symptoms, and anxiety. Body composition and dietary intake were assessed. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Galectin-3, TGF-β, and PAI-1.<h4>Results</h4>No significant difference was observed regarding Galectin-3, TGF-β, and PAI-1 levels between the groups with dissimilar adherence to LCD or the groups with different levels of depressive symptoms (P>0.05). However, there was a negative association between LCD score as a covariant and depressive symptoms as an independent variable (P = 0.02) and remarkably, a regression model linear analysis using Galectin-3, TGF-β, and PAI-1 as confounding variables indicated the mediatory role of these adipokines in this association (P>0.05). In other words, adipokines eliminated the significance of the relationship between adherence to LCD and depressive symptoms.<h4>Conclusion</h4>It seems that higher adherence to LCD is probably associated with a lower prevalence of depressive symptoms in obese adults through the mediatory role of adipokines.Leila SetayeshReyhane EbrahimiSara PooyanHabib YarizadehElaheh RashidbeygiNegin BadroojHossein ImaniKhadijeh MirzaeiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257275 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leila Setayesh Reyhane Ebrahimi Sara Pooyan Habib Yarizadeh Elaheh Rashidbeygi Negin Badrooj Hossein Imani Khadijeh Mirzaei The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.
description	<h4>Background</h4>Previous studies showed the possible association between obesity, dietary pattern, and depressive symptoms. Due to the lack of enough data to confirm the association of obesity and depression in the Middle East, here, we aimed to explore the possible mediatory role of adipokines Galectin-3, transforming growth factor-beta (TGF-β), and endothelial plasminogen activator inhibitor (PAI-1) in the association between low carbohydrate diet (LCD) and depressive symptoms.<h4>Methods</h4>A total of 256 women aged 17-56 years old were grouped based on their LCD score. Depression anxiety stress scales-21 (DASS-21) self-administered questionnaire was used to evaluate the three negative emotional states of stress, depressive symptoms, and anxiety. Body composition and dietary intake were assessed. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Galectin-3, TGF-β, and PAI-1.<h4>Results</h4>No significant difference was observed regarding Galectin-3, TGF-β, and PAI-1 levels between the groups with dissimilar adherence to LCD or the groups with different levels of depressive symptoms (P>0.05). However, there was a negative association between LCD score as a covariant and depressive symptoms as an independent variable (P = 0.02) and remarkably, a regression model linear analysis using Galectin-3, TGF-β, and PAI-1 as confounding variables indicated the mediatory role of these adipokines in this association (P>0.05). In other words, adipokines eliminated the significance of the relationship between adherence to LCD and depressive symptoms.<h4>Conclusion</h4>It seems that higher adherence to LCD is probably associated with a lower prevalence of depressive symptoms in obese adults through the mediatory role of adipokines.
format	article
author	Leila Setayesh Reyhane Ebrahimi Sara Pooyan Habib Yarizadeh Elaheh Rashidbeygi Negin Badrooj Hossein Imani Khadijeh Mirzaei
author_facet	Leila Setayesh Reyhane Ebrahimi Sara Pooyan Habib Yarizadeh Elaheh Rashidbeygi Negin Badrooj Hossein Imani Khadijeh Mirzaei
author_sort	Leila Setayesh
title	The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.
title_short	The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.
title_full	The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.
title_fullStr	The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.
title_full_unstemmed	The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.
title_sort	possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c0857460905d44e69e0e3d3bffd8d1d1
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The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women.

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