Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with survival, in addition to the early emergence of meta...

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Autores principales:	Nathaniel D. Anderson, Yael Babichev, Fabio Fuligni, Federico Comitani, Mehdi Layeghifard, Rosemarie E. Venier, Stefan C. Dentro, Anant Maheshwari, Sheena Guram, Claire Wunker, J. Drew Thompson, Kyoko E. Yuki, Huayun Hou, Matthew Zatzman, Nicholas Light, Marcus Q. Bernardini, Jay S. Wunder, Irene L. Andrulis, Peter Ferguson, Albiruni R. Abdul Razak, Carol J. Swallow, James J. Dowling, Rima S. Al-Awar, Richard Marcellus, Marjan Rouzbahman, Moritz Gerstung, Daniel Durocher, Ludmil B. Alexandrov, Brendan C. Dickson, Rebecca A. Gladdy, Adam Shlien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c08bf52065ac4dcd90672db6a2810128
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spelling	oai:doaj.org-article:c08bf52065ac4dcd90672db6a28101282021-12-02T16:26:25ZLineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival10.1038/s41467-021-24677-62041-1723https://doaj.org/article/c08bf52065ac4dcd90672db6a28101282021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24677-6https://doaj.org/toc/2041-1723Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with survival, in addition to the early emergence of metastatic clones.Nathaniel D. AndersonYael BabichevFabio FuligniFederico ComitaniMehdi LayeghifardRosemarie E. VenierStefan C. DentroAnant MaheshwariSheena GuramClaire WunkerJ. Drew ThompsonKyoko E. YukiHuayun HouMatthew ZatzmanNicholas LightMarcus Q. BernardiniJay S. WunderIrene L. AndrulisPeter FergusonAlbiruni R. Abdul RazakCarol J. SwallowJames J. DowlingRima S. Al-AwarRichard MarcellusMarjan RouzbahmanMoritz GerstungDaniel DurocherLudmil B. AlexandrovBrendan C. DicksonRebecca A. GladdyAdam ShlienNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathaniel D. Anderson Yael Babichev Fabio Fuligni Federico Comitani Mehdi Layeghifard Rosemarie E. Venier Stefan C. Dentro Anant Maheshwari Sheena Guram Claire Wunker J. Drew Thompson Kyoko E. Yuki Huayun Hou Matthew Zatzman Nicholas Light Marcus Q. Bernardini Jay S. Wunder Irene L. Andrulis Peter Ferguson Albiruni R. Abdul Razak Carol J. Swallow James J. Dowling Rima S. Al-Awar Richard Marcellus Marjan Rouzbahman Moritz Gerstung Daniel Durocher Ludmil B. Alexandrov Brendan C. Dickson Rebecca A. Gladdy Adam Shlien Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
description	Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with survival, in addition to the early emergence of metastatic clones.
format	article
author	Nathaniel D. Anderson Yael Babichev Fabio Fuligni Federico Comitani Mehdi Layeghifard Rosemarie E. Venier Stefan C. Dentro Anant Maheshwari Sheena Guram Claire Wunker J. Drew Thompson Kyoko E. Yuki Huayun Hou Matthew Zatzman Nicholas Light Marcus Q. Bernardini Jay S. Wunder Irene L. Andrulis Peter Ferguson Albiruni R. Abdul Razak Carol J. Swallow James J. Dowling Rima S. Al-Awar Richard Marcellus Marjan Rouzbahman Moritz Gerstung Daniel Durocher Ludmil B. Alexandrov Brendan C. Dickson Rebecca A. Gladdy Adam Shlien
author_facet	Nathaniel D. Anderson Yael Babichev Fabio Fuligni Federico Comitani Mehdi Layeghifard Rosemarie E. Venier Stefan C. Dentro Anant Maheshwari Sheena Guram Claire Wunker J. Drew Thompson Kyoko E. Yuki Huayun Hou Matthew Zatzman Nicholas Light Marcus Q. Bernardini Jay S. Wunder Irene L. Andrulis Peter Ferguson Albiruni R. Abdul Razak Carol J. Swallow James J. Dowling Rima S. Al-Awar Richard Marcellus Marjan Rouzbahman Moritz Gerstung Daniel Durocher Ludmil B. Alexandrov Brendan C. Dickson Rebecca A. Gladdy Adam Shlien
author_sort	Nathaniel D. Anderson
title	Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
title_short	Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
title_full	Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
title_fullStr	Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
title_full_unstemmed	Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
title_sort	lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c08bf52065ac4dcd90672db6a2810128
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Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

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