Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I
Glyoxalase I converts toxic methylglyoxal to a thioester. Here the authors report a synthetic analogue capable of enantioselectively converting alpha-keto aldehydes to thioesters via formation of a hemithioacetal, giving access to both enantiomers of a range of alpha-hydroxy thioesters.
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Nature Portfolio
2017
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oai:doaj.org-article:c08c3385ef2e49d894130b8a5338b2082021-12-02T14:42:33ZBiomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I10.1038/ncomms148772041-1723https://doaj.org/article/c08c3385ef2e49d894130b8a5338b2082017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14877https://doaj.org/toc/2041-1723Glyoxalase I converts toxic methylglyoxal to a thioester. Here the authors report a synthetic analogue capable of enantioselectively converting alpha-keto aldehydes to thioesters via formation of a hemithioacetal, giving access to both enantiomers of a range of alpha-hydroxy thioesters.Sang Yeon ParkIn-Soo HwangHyun-Ju LeeChoong Eui SongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
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DOAJ |
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Science Q |
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Science Q Sang Yeon Park In-Soo Hwang Hyun-Ju Lee Choong Eui Song Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I |
| description |
Glyoxalase I converts toxic methylglyoxal to a thioester. Here the authors report a synthetic analogue capable of enantioselectively converting alpha-keto aldehydes to thioesters via formation of a hemithioacetal, giving access to both enantiomers of a range of alpha-hydroxy thioesters. |
| format |
article |
| author |
Sang Yeon Park In-Soo Hwang Hyun-Ju Lee Choong Eui Song |
| author_facet |
Sang Yeon Park In-Soo Hwang Hyun-Ju Lee Choong Eui Song |
| author_sort |
Sang Yeon Park |
| title |
Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I |
| title_short |
Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I |
| title_full |
Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I |
| title_fullStr |
Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I |
| title_full_unstemmed |
Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I |
| title_sort |
biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase i |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/c08c3385ef2e49d894130b8a5338b208 |
| work_keys_str_mv |
AT sangyeonpark biomimeticcatalytictransformationoftoxicaoxoaldehydestohighvaluechiralahydroxythioestersusingartificialglyoxalasei AT insoohwang biomimeticcatalytictransformationoftoxicaoxoaldehydestohighvaluechiralahydroxythioestersusingartificialglyoxalasei AT hyunjulee biomimeticcatalytictransformationoftoxicaoxoaldehydestohighvaluechiralahydroxythioestersusingartificialglyoxalasei AT choongeuisong biomimeticcatalytictransformationoftoxicaoxoaldehydestohighvaluechiralahydroxythioestersusingartificialglyoxalasei |
| _version_ |
1718389656613027840 |