Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients

Ida Vikan Rise,1 Josep Maria Haro,2–4 Bjørn Gjervan,5,61Department of Psychiatry, Sorlandet Hospital, Arendal, Norway; 2Research Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain; 3Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain; 4CIBE...

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Autores principales:	Rise IV, Haro JM, Gjervan B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	bipolar disorder comorbidity cognition Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c08e89c9b17c4a189263a7a092c6432d
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spelling	oai:doaj.org-article:c08e89c9b17c4a189263a7a092c6432d2021-12-02T04:18:44ZClinical features, comorbidity, and cognitive impairment in elderly bipolar patients1178-2021https://doaj.org/article/c08e89c9b17c4a189263a7a092c6432d2016-05-01T00:00:00Zhttps://www.dovepress.com/clinical-features-comorbidity-and-cognitive-impairment-in-elderly-bipo-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ida Vikan Rise,1 Josep Maria Haro,2–4 Bjørn Gjervan,5,61Department of Psychiatry, Sorlandet Hospital, Arendal, Norway; 2Research Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain; 3Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain; 4CIBERSAM (Centro de Investigación Biomédica En Red de Salud Mental), Madrid, Spain; 5Department of Psychiatry, North-Trondelag Hospital Trust, Levanger, Norway; 6Department of Medicine, Institute of Neuromedicine, Norwegian University of Science and Technology, Trondheim, NorwayIntroduction: Data specific to late-life bipolar disorder (BD) are limited. Current research is sparse and present guidelines are not adapted to this group of patients.Objectives: We present a literature review on clinical characteristics, comorbidities, and cognitive impairment in patients with late-life BD. This review discusses common comorbidities that affect BD elders and how aging might affect cognition and treatment.Methods: Eligible studies were identified in MedLine by the Medical Subject Headings terms “bipolar disorder” and “aged”. We only included original research reports published in English between 2012 and 2015.Results: From 414 articles extracted, 16 studies were included in the review. Cardiovascular and respiratory conditions, type II diabetes, and endocrinological abnormalities were observed as highly prevalent. BD is associated with a high suicide risk. Bipolar elderly had an increased risk of dementia and performed worse on cognitive screening tests compared to age-matched controls across different levels of cognition. Despite high rates of medical comorbidity among bipolar elderly, a systematic under-recognition and undertreatment of cardiovascular disease have been suggested.Conclusion: There was a high burden of physical comorbidities and cognitive impairment in late-life BD. Bipolar elderly might be under-recorded and undertreated in primary medical care, indicating that this group needs an adapted clinical assessment and specific clinical guidelines need to be established.Keywords: bipolar disorder, aged, comorbidity, cognition, impairment, treatmentRise IVHaro JMGjervan BDove Medical Pressarticlebipolar disordercomorbiditycognitionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1203-1213 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder comorbidity cognition Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	bipolar disorder comorbidity cognition Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Rise IV Haro JM Gjervan B Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients
description	Ida Vikan Rise,1 Josep Maria Haro,2–4 Bjørn Gjervan,5,61Department of Psychiatry, Sorlandet Hospital, Arendal, Norway; 2Research Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain; 3Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain; 4CIBERSAM (Centro de Investigación Biomédica En Red de Salud Mental), Madrid, Spain; 5Department of Psychiatry, North-Trondelag Hospital Trust, Levanger, Norway; 6Department of Medicine, Institute of Neuromedicine, Norwegian University of Science and Technology, Trondheim, NorwayIntroduction: Data specific to late-life bipolar disorder (BD) are limited. Current research is sparse and present guidelines are not adapted to this group of patients.Objectives: We present a literature review on clinical characteristics, comorbidities, and cognitive impairment in patients with late-life BD. This review discusses common comorbidities that affect BD elders and how aging might affect cognition and treatment.Methods: Eligible studies were identified in MedLine by the Medical Subject Headings terms “bipolar disorder” and “aged”. We only included original research reports published in English between 2012 and 2015.Results: From 414 articles extracted, 16 studies were included in the review. Cardiovascular and respiratory conditions, type II diabetes, and endocrinological abnormalities were observed as highly prevalent. BD is associated with a high suicide risk. Bipolar elderly had an increased risk of dementia and performed worse on cognitive screening tests compared to age-matched controls across different levels of cognition. Despite high rates of medical comorbidity among bipolar elderly, a systematic under-recognition and undertreatment of cardiovascular disease have been suggested.Conclusion: There was a high burden of physical comorbidities and cognitive impairment in late-life BD. Bipolar elderly might be under-recorded and undertreated in primary medical care, indicating that this group needs an adapted clinical assessment and specific clinical guidelines need to be established.Keywords: bipolar disorder, aged, comorbidity, cognition, impairment, treatment
format	article
author	Rise IV Haro JM Gjervan B
author_facet	Rise IV Haro JM Gjervan B
author_sort	Rise IV
title	Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients
title_short	Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients
title_full	Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients
title_fullStr	Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients
title_full_unstemmed	Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients
title_sort	clinical features, comorbidity, and cognitive impairment in elderly bipolar patients
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c08e89c9b17c4a189263a7a092c6432d
work_keys_str_mv	AT riseiv clinicalfeaturescomorbidityandcognitiveimpairmentinelderlybipolarpatients AT harojm clinicalfeaturescomorbidityandcognitiveimpairmentinelderlybipolarpatients AT gjervanb clinicalfeaturescomorbidityandcognitiveimpairmentinelderlybipolarpatients
_version_	1718401332833943552

Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients

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