A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay

Nonsense-mediated decay (NMD) eliminates transcripts with premature stop codons and has been linked to cancer genesis. Here, the authors develop an algorithm to predict NMD and perform a pan-cancer analysis that finds that some hypermutated cancers are dependent on mutations that elicit NMD.

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Detalles Bibliográficos
Autores principales: Zhiyuan Hu, Christopher Yau, Ahmed Ashour Ahmed
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c0902411e9254fe9a4526480dee78352
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Sumario:Nonsense-mediated decay (NMD) eliminates transcripts with premature stop codons and has been linked to cancer genesis. Here, the authors develop an algorithm to predict NMD and perform a pan-cancer analysis that finds that some hypermutated cancers are dependent on mutations that elicit NMD.