A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay

Nonsense-mediated decay (NMD) eliminates transcripts with premature stop codons and has been linked to cancer genesis. Here, the authors develop an algorithm to predict NMD and perform a pan-cancer analysis that finds that some hypermutated cancers are dependent on mutations that elicit NMD.

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Autores principales:	Zhiyuan Hu, Christopher Yau, Ahmed Ashour Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0902411e9254fe9a4526480dee78352
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spelling	oai:doaj.org-article:c0902411e9254fe9a4526480dee783522021-12-02T15:38:48ZA pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay10.1038/ncomms159432041-1723https://doaj.org/article/c0902411e9254fe9a4526480dee783522017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15943https://doaj.org/toc/2041-1723Nonsense-mediated decay (NMD) eliminates transcripts with premature stop codons and has been linked to cancer genesis. Here, the authors develop an algorithm to predict NMD and perform a pan-cancer analysis that finds that some hypermutated cancers are dependent on mutations that elicit NMD.Zhiyuan HuChristopher YauAhmed Ashour AhmedNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiyuan Hu Christopher Yau Ahmed Ashour Ahmed A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
description	Nonsense-mediated decay (NMD) eliminates transcripts with premature stop codons and has been linked to cancer genesis. Here, the authors develop an algorithm to predict NMD and perform a pan-cancer analysis that finds that some hypermutated cancers are dependent on mutations that elicit NMD.
format	article
author	Zhiyuan Hu Christopher Yau Ahmed Ashour Ahmed
author_facet	Zhiyuan Hu Christopher Yau Ahmed Ashour Ahmed
author_sort	Zhiyuan Hu
title	A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
title_short	A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
title_full	A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
title_fullStr	A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
title_full_unstemmed	A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
title_sort	pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c0902411e9254fe9a4526480dee78352
work_keys_str_mv	AT zhiyuanhu apancancergenomewideanalysisrevealstumourdependenciesbyinductionofnonsensemediateddecay AT christopheryau apancancergenomewideanalysisrevealstumourdependenciesbyinductionofnonsensemediateddecay AT ahmedashourahmed apancancergenomewideanalysisrevealstumourdependenciesbyinductionofnonsensemediateddecay AT zhiyuanhu pancancergenomewideanalysisrevealstumourdependenciesbyinductionofnonsensemediateddecay AT christopheryau pancancergenomewideanalysisrevealstumourdependenciesbyinductionofnonsensemediateddecay AT ahmedashourahmed pancancergenomewideanalysisrevealstumourdependenciesbyinductionofnonsensemediateddecay
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A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay

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