A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay

Nonsense-mediated decay (NMD) eliminates transcripts with premature stop codons and has been linked to cancer genesis. Here, the authors develop an algorithm to predict NMD and perform a pan-cancer analysis that finds that some hypermutated cancers are dependent on mutations that elicit NMD.

Guardado en:
Detalles Bibliográficos
Autores principales: Zhiyuan Hu, Christopher Yau, Ahmed Ashour Ahmed
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/c0902411e9254fe9a4526480dee78352
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares