Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review

The serendipitous discovery of ketamine’s antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years. Ketamine provides an exciting challenge to traditional concepts of antidepressant drug therapy, producing rapid antidepressant effects s...

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Autores principales:	Michael Colla, Hanne Scheerer, Steffi Weidt, Erich Seifritz, Golo Kronenberg
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	depression antidepressant treatment-resistant depression ketamine BDNF neurogenesis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c092f7b28ea94208a4a9a04231bffbee
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spelling	oai:doaj.org-article:c092f7b28ea94208a4a9a04231bffbee2021-12-03T15:59:08ZNovel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review1662-515310.3389/fnbeh.2021.759466https://doaj.org/article/c092f7b28ea94208a4a9a04231bffbee2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.759466/fullhttps://doaj.org/toc/1662-5153The serendipitous discovery of ketamine’s antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years. Ketamine provides an exciting challenge to traditional concepts of antidepressant drug therapy, producing rapid antidepressant effects seemingly without targeting monoaminergic pathways in the conventional way. In consequence, the advent of ketamine has spawned a plethora of neurobiological research into its putative mechanisms. Here, we provide a brief overview of current theories of antidepressant drug action including monoaminergic signaling, disinhibition of glutamatergic neurotransmission, neurotrophic and neuroplastic effects, and how these might relate to ketamine. Given that research into ketamine has not yet yielded new therapies beyond ketamine itself, current knowledge gaps and limitations of available studies are also discussed.Michael CollaHanne ScheererSteffi WeidtErich SeifritzGolo KronenbergFrontiers Media S.A.articledepressionantidepressanttreatment-resistant depressionketamineBDNFneurogenesisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression antidepressant treatment-resistant depression ketamine BDNF neurogenesis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	depression antidepressant treatment-resistant depression ketamine BDNF neurogenesis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Michael Colla Hanne Scheerer Steffi Weidt Erich Seifritz Golo Kronenberg Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review
description	The serendipitous discovery of ketamine’s antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years. Ketamine provides an exciting challenge to traditional concepts of antidepressant drug therapy, producing rapid antidepressant effects seemingly without targeting monoaminergic pathways in the conventional way. In consequence, the advent of ketamine has spawned a plethora of neurobiological research into its putative mechanisms. Here, we provide a brief overview of current theories of antidepressant drug action including monoaminergic signaling, disinhibition of glutamatergic neurotransmission, neurotrophic and neuroplastic effects, and how these might relate to ketamine. Given that research into ketamine has not yet yielded new therapies beyond ketamine itself, current knowledge gaps and limitations of available studies are also discussed.
format	article
author	Michael Colla Hanne Scheerer Steffi Weidt Erich Seifritz Golo Kronenberg
author_facet	Michael Colla Hanne Scheerer Steffi Weidt Erich Seifritz Golo Kronenberg
author_sort	Michael Colla
title	Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review
title_short	Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review
title_full	Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review
title_fullStr	Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review
title_full_unstemmed	Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review
title_sort	novel insights into the neurobiology of the antidepressant response from ketamine research: a mini review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c092f7b28ea94208a4a9a04231bffbee
work_keys_str_mv	AT michaelcolla novelinsightsintotheneurobiologyoftheantidepressantresponsefromketamineresearchaminireview AT hannescheerer novelinsightsintotheneurobiologyoftheantidepressantresponsefromketamineresearchaminireview AT steffiweidt novelinsightsintotheneurobiologyoftheantidepressantresponsefromketamineresearchaminireview AT erichseifritz novelinsightsintotheneurobiologyoftheantidepressantresponsefromketamineresearchaminireview AT golokronenberg novelinsightsintotheneurobiologyoftheantidepressantresponsefromketamineresearchaminireview
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Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review

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