Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections

Abstract Whether post injectional acute intraocular pressure (IOP) increase is associated with decreased peripapillary and macular perfusion is still under debate. Here, we investigated early changes in the choroidal and retinal blood flow using OCTA imaging in a cohort of patients undergoing anti-V...

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Autores principales:	Nadhini Arumuganathan, Maximilian Robert Justus Wiest, Mario Damiano Toro, Timothy Hamann, Katrin Fasler, Sandrine Anne Zweifel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0931489dc1c4949b23774701491ab9a
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spelling	oai:doaj.org-article:c0931489dc1c4949b23774701491ab9a2021-12-02T17:37:29ZAcute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections10.1038/s41598-021-98850-82045-2322https://doaj.org/article/c0931489dc1c4949b23774701491ab9a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98850-8https://doaj.org/toc/2045-2322Abstract Whether post injectional acute intraocular pressure (IOP) increase is associated with decreased peripapillary and macular perfusion is still under debate. Here, we investigated early changes in the choroidal and retinal blood flow using OCTA imaging in a cohort of patients undergoing anti-VEGF intravitreal injections (IVI) for macular edema following retinal vein occlusion and diabetic retinopathy. In this prospective single-center, observational study, the pre- and post-IVI changes in retinal perfusion were examined via assessment of vessel length density (VLD) and vessel density (VD) in deep and superficial capillary segmentations (DCP and SCP), foveal avascular zone (FAZ) in SCP, as well as flow signal deficits in the choriocapillaris segmentation. Mean IOP significantly changed over the study course (p = 0.000; ANOVA). Measurements at 5 min post-IVI (33.48 ± 10.84 mmHg) differed significantly from baseline (17.26 ± 2.41 mmHg, p = 0.000), while measurements from one day, one week, and one-month post-IVI did not (p = 0.907, p = 1.000 and p = 1.000 respectively). In comparison to baseline, no changes in OCTA parameters, including FAZ, VD, VLD, and FV, were detected 5 min post-IVI. No significant alterations in OCTA parameters were observed during study course. Increased IOP spikes were detected post-IVI; however, no potential permanent ischemic retinal damage was suspected.Nadhini ArumuganathanMaximilian Robert Justus WiestMario Damiano ToroTimothy HamannKatrin FaslerSandrine Anne ZweifelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadhini Arumuganathan Maximilian Robert Justus Wiest Mario Damiano Toro Timothy Hamann Katrin Fasler Sandrine Anne Zweifel Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
description	Abstract Whether post injectional acute intraocular pressure (IOP) increase is associated with decreased peripapillary and macular perfusion is still under debate. Here, we investigated early changes in the choroidal and retinal blood flow using OCTA imaging in a cohort of patients undergoing anti-VEGF intravitreal injections (IVI) for macular edema following retinal vein occlusion and diabetic retinopathy. In this prospective single-center, observational study, the pre- and post-IVI changes in retinal perfusion were examined via assessment of vessel length density (VLD) and vessel density (VD) in deep and superficial capillary segmentations (DCP and SCP), foveal avascular zone (FAZ) in SCP, as well as flow signal deficits in the choriocapillaris segmentation. Mean IOP significantly changed over the study course (p = 0.000; ANOVA). Measurements at 5 min post-IVI (33.48 ± 10.84 mmHg) differed significantly from baseline (17.26 ± 2.41 mmHg, p = 0.000), while measurements from one day, one week, and one-month post-IVI did not (p = 0.907, p = 1.000 and p = 1.000 respectively). In comparison to baseline, no changes in OCTA parameters, including FAZ, VD, VLD, and FV, were detected 5 min post-IVI. No significant alterations in OCTA parameters were observed during study course. Increased IOP spikes were detected post-IVI; however, no potential permanent ischemic retinal damage was suspected.
format	article
author	Nadhini Arumuganathan Maximilian Robert Justus Wiest Mario Damiano Toro Timothy Hamann Katrin Fasler Sandrine Anne Zweifel
author_facet	Nadhini Arumuganathan Maximilian Robert Justus Wiest Mario Damiano Toro Timothy Hamann Katrin Fasler Sandrine Anne Zweifel
author_sort	Nadhini Arumuganathan
title	Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_short	Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_full	Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_fullStr	Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_full_unstemmed	Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_sort	acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0931489dc1c4949b23774701491ab9a
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Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections

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