Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study

We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with...

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Autores principales:	Carl Llor, Dan Ouchi, Maria Giner-Soriano, Ana García-Sangenís, Lars Bjerrum, Rosa Morros
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug resistance microbial primary health care COVID-19 anti-bacterial agents Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c095540887ea45bf9e6a13a13e8e8c58
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spelling	oai:doaj.org-article:c095540887ea45bf9e6a13a13e8e8c582021-11-25T16:23:45ZCorrelation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study10.3390/antibiotics101113642079-6382https://doaj.org/article/c095540887ea45bf9e6a13a13e8e8c582021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1364https://doaj.org/toc/2079-6382We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease.Carl LlorDan OuchiMaria Giner-SorianoAna García-SangenísLars BjerrumRosa MorrosMDPI AGarticledrug resistancemicrobialprimary health careCOVID-19anti-bacterial agentsTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1364, p 1364 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug resistance microbial primary health care COVID-19 anti-bacterial agents Therapeutics. Pharmacology RM1-950
spellingShingle	drug resistance microbial primary health care COVID-19 anti-bacterial agents Therapeutics. Pharmacology RM1-950 Carl Llor Dan Ouchi Maria Giner-Soriano Ana García-Sangenís Lars Bjerrum Rosa Morros Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
description	We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease.
format	article
author	Carl Llor Dan Ouchi Maria Giner-Soriano Ana García-Sangenís Lars Bjerrum Rosa Morros
author_facet	Carl Llor Dan Ouchi Maria Giner-Soriano Ana García-Sangenís Lars Bjerrum Rosa Morros
author_sort	Carl Llor
title	Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_short	Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_full	Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_fullStr	Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_full_unstemmed	Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_sort	correlation between previous antibiotic exposure and covid-19 severity. a population-based cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c095540887ea45bf9e6a13a13e8e8c58
work_keys_str_mv	AT carlllor correlationbetweenpreviousantibioticexposureandcovid19severityapopulationbasedcohortstudy AT danouchi correlationbetweenpreviousantibioticexposureandcovid19severityapopulationbasedcohortstudy AT mariaginersoriano correlationbetweenpreviousantibioticexposureandcovid19severityapopulationbasedcohortstudy AT anagarciasangenis correlationbetweenpreviousantibioticexposureandcovid19severityapopulationbasedcohortstudy AT larsbjerrum correlationbetweenpreviousantibioticexposureandcovid19severityapopulationbasedcohortstudy AT rosamorros correlationbetweenpreviousantibioticexposureandcovid19severityapopulationbasedcohortstudy
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Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study

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