GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation

IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and i...

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Autores principales:	Steven Offenbacher, Yizu Jiao, Steven J. Kim, Julie Marchesan, Kevin L. Moss, Li Jing, Kimon Divaris, Sompop Bencharit, Cary S. Agler, Thiago Morelli, Shaoping Zhang, Lu Sun, William T. Seaman, Dale Cowley, Silvana P. Barros, James D. Beck, Matthias Munz, Arne S. Schaefer, Kari E. North
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c09756d6c83548c2b068a9c266188a12
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spelling	oai:doaj.org-article:c09756d6c83548c2b068a9c266188a122021-12-02T15:33:46ZGWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation10.1038/s41467-018-05940-92041-1723https://doaj.org/article/c09756d6c83548c2b068a9c266188a122018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05940-9https://doaj.org/toc/2041-1723IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and in vivo.Steven OffenbacherYizu JiaoSteven J. KimJulie MarchesanKevin L. MossLi JingKimon DivarisSompop BencharitCary S. AglerThiago MorelliShaoping ZhangLu SunWilliam T. SeamanDale CowleySilvana P. BarrosJames D. BeckMatthias MunzArne S. SchaeferKari E. NorthNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steven Offenbacher Yizu Jiao Steven J. Kim Julie Marchesan Kevin L. Moss Li Jing Kimon Divaris Sompop Bencharit Cary S. Agler Thiago Morelli Shaoping Zhang Lu Sun William T. Seaman Dale Cowley Silvana P. Barros James D. Beck Matthias Munz Arne S. Schaefer Kari E. North GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
description	IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and in vivo.
format	article
author	Steven Offenbacher Yizu Jiao Steven J. Kim Julie Marchesan Kevin L. Moss Li Jing Kimon Divaris Sompop Bencharit Cary S. Agler Thiago Morelli Shaoping Zhang Lu Sun William T. Seaman Dale Cowley Silvana P. Barros James D. Beck Matthias Munz Arne S. Schaefer Kari E. North
author_facet	Steven Offenbacher Yizu Jiao Steven J. Kim Julie Marchesan Kevin L. Moss Li Jing Kimon Divaris Sompop Bencharit Cary S. Agler Thiago Morelli Shaoping Zhang Lu Sun William T. Seaman Dale Cowley Silvana P. Barros James D. Beck Matthias Munz Arne S. Schaefer Kari E. North
author_sort	Steven Offenbacher
title	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_short	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_full	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_fullStr	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_full_unstemmed	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_sort	gwas for interleukin-1β levels in gingival crevicular fluid identifies il37 variants in periodontal inflammation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c09756d6c83548c2b068a9c266188a12
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GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation

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