Ocular higher-order aberrations and axial eye growth in young Hong Kong children
Abstract This retrospective longitudinal analysis aimed to investigate the association between ocular higher-order aberrations (HOAs) and axial eye growth in Hong Kong children. Measures of axial length and ocular HOAs under cycloplegia were obtained annually over a two-year period from 137 subjects...
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Nature Portfolio
2018
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oai:doaj.org-article:c0997b56005c4b13884db6f13a3470002021-12-02T12:33:01ZOcular higher-order aberrations and axial eye growth in young Hong Kong children10.1038/s41598-018-24906-x2045-2322https://doaj.org/article/c0997b56005c4b13884db6f13a3470002018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24906-xhttps://doaj.org/toc/2045-2322Abstract This retrospective longitudinal analysis aimed to investigate the association between ocular higher-order aberrations (HOAs) and axial eye growth in Hong Kong children. Measures of axial length and ocular HOAs under cycloplegia were obtained annually over a two-year period from 137 subjects aged 8.8 ± 1.4 years with mean spherical equivalent refraction of −2.04 ± 2.38 D. A significant negative association was observed between the RMS of total HOAs and axial eye growth (P = 0.03), after adjusting for other significant predictors of axial length including age, sex and refractive error. Similar negative associations with axial elongation were found for the RMS of spherical aberrations ($${{\rm{Z}}}_{4}^{0}$$ Z40 and $${{\rm{Z}}}_{6}^{0}$$ Z60 combined) (P = 0.037). Another linear mixed model also showed that greater levels of vertical trefoil $$({{\rm{Z}}}_{3}^{-3})$$ (Z3−3) , primary spherical aberration $$({{\rm{Z}}}_{4}^{0})$$ (Z40) and negative oblique trefoil $$({{\rm{Z}}}_{3}^{3})$$ (Z33) were associated with slower axial elongation and longer axial length (all P < 0.05). These findings support the potential role of HOAs, image quality and a vision-dependent mechanism in childhood eye growth.Jason K. LauStephen J. VincentMichael J. CollinsSin-Wan CheungPauline ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Jason K. Lau Stephen J. Vincent Michael J. Collins Sin-Wan Cheung Pauline Cho Ocular higher-order aberrations and axial eye growth in young Hong Kong children |
| description |
Abstract This retrospective longitudinal analysis aimed to investigate the association between ocular higher-order aberrations (HOAs) and axial eye growth in Hong Kong children. Measures of axial length and ocular HOAs under cycloplegia were obtained annually over a two-year period from 137 subjects aged 8.8 ± 1.4 years with mean spherical equivalent refraction of −2.04 ± 2.38 D. A significant negative association was observed between the RMS of total HOAs and axial eye growth (P = 0.03), after adjusting for other significant predictors of axial length including age, sex and refractive error. Similar negative associations with axial elongation were found for the RMS of spherical aberrations ($${{\rm{Z}}}_{4}^{0}$$ Z40 and $${{\rm{Z}}}_{6}^{0}$$ Z60 combined) (P = 0.037). Another linear mixed model also showed that greater levels of vertical trefoil $$({{\rm{Z}}}_{3}^{-3})$$ (Z3−3) , primary spherical aberration $$({{\rm{Z}}}_{4}^{0})$$ (Z40) and negative oblique trefoil $$({{\rm{Z}}}_{3}^{3})$$ (Z33) were associated with slower axial elongation and longer axial length (all P < 0.05). These findings support the potential role of HOAs, image quality and a vision-dependent mechanism in childhood eye growth. |
| format |
article |
| author |
Jason K. Lau Stephen J. Vincent Michael J. Collins Sin-Wan Cheung Pauline Cho |
| author_facet |
Jason K. Lau Stephen J. Vincent Michael J. Collins Sin-Wan Cheung Pauline Cho |
| author_sort |
Jason K. Lau |
| title |
Ocular higher-order aberrations and axial eye growth in young Hong Kong children |
| title_short |
Ocular higher-order aberrations and axial eye growth in young Hong Kong children |
| title_full |
Ocular higher-order aberrations and axial eye growth in young Hong Kong children |
| title_fullStr |
Ocular higher-order aberrations and axial eye growth in young Hong Kong children |
| title_full_unstemmed |
Ocular higher-order aberrations and axial eye growth in young Hong Kong children |
| title_sort |
ocular higher-order aberrations and axial eye growth in young hong kong children |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/c0997b56005c4b13884db6f13a347000 |
| work_keys_str_mv |
AT jasonklau ocularhigherorderaberrationsandaxialeyegrowthinyounghongkongchildren AT stephenjvincent ocularhigherorderaberrationsandaxialeyegrowthinyounghongkongchildren AT michaeljcollins ocularhigherorderaberrationsandaxialeyegrowthinyounghongkongchildren AT sinwancheung ocularhigherorderaberrationsandaxialeyegrowthinyounghongkongchildren AT paulinecho ocularhigherorderaberrationsandaxialeyegrowthinyounghongkongchildren |
| _version_ |
1718393883064270848 |