Analysis of the central zone of the retina in patients with diabetic macular edema

Aim. To assess morphological changes of retinal layers and optical density of macular pigment in patients with diabetic macular edema (DME) for the diagnostic criterion of pathological process.Materials and methods. 31 patients were divided in two groups. The first group (A) included 19 patients wit...

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Autores principales:	Mukharram Muhtaramovich Bikbov, Rinat Rustamovich Fayzrakhmanov, Alia Linarovna Yarmuhametova, Rinat Mukhametovich Zainullin
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	diabetic macular edema macular pigment optical density optical coherence tomography microperimetry Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c0a4aa04e70c4287bf8cb2d0bee0b4a5
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spelling	oai:doaj.org-article:c0a4aa04e70c4287bf8cb2d0bee0b4a52021-11-14T09:00:20ZAnalysis of the central zone of the retina in patients with diabetic macular edema2072-03512072-037810.14341/DM7126https://doaj.org/article/c0a4aa04e70c4287bf8cb2d0bee0b4a52015-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7126https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To assess morphological changes of retinal layers and optical density of macular pigment in patients with diabetic macular edema (DME) for the diagnostic criterion of pathological process.Materials and methods. 31 patients were divided in two groups. The first group (A) included 19 patients with DME (20 eyes), the second group (B) – 12 patients (20 eyes) without retinal pathology. Both groups were comparable with regard to age. Parameter estimation was conducted with the use of following methods: optical coherence tomography (OCT) of the macular area of the retina; fundus photography with the measurement of macular pigment optical density (MPOD); microperimetry.Results. OCT analysis showed that the inner nuclear and plexiform layers of retina were the most involved in pathological process and revealed significant differences in increase of mean retinal thickness in comparison with the control group. Analysis of MPOD revealed a significant reduction of all parameters in group A compared with the control group. On the basis of microperimetry of the central area of retina in group A light sensitivity indicators were reduced by an average of 9 dB and equaled 9.85 ± 0.09 dB. The analysis showed gross violations of retinal structure and distribution of optical density of macular pigment in patients with DME. Correlation analysis of retinal thickness, functional light sensitivity and optical density of macular pigment traced a strong connection (r = -0.93; p <0.05) between the indices of retinal thickness and MPOD.Conclusions. Diabetic macular edema showed a sharp decrease in optical density of macular pigment determined by deficiency of lutein and zeaxantin. A correlation between quantitative indicator of optical density of macular pigment and area of edema was established. Light sensitivity was significantly reduced in the central part of the retina.Mukharram Muhtaramovich BikbovRinat Rustamovich FayzrakhmanovAlia Linarovna YarmuhametovaRinat Mukhametovich ZainullinEndocrinology Research Centrearticlediabetic macular edemamacular pigment optical densityoptical coherence tomographymicroperimetryNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 4, Pp 99-104 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetic macular edema macular pigment optical density optical coherence tomography microperimetry Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetic macular edema macular pigment optical density optical coherence tomography microperimetry Nutritional diseases. Deficiency diseases RC620-627 Mukharram Muhtaramovich Bikbov Rinat Rustamovich Fayzrakhmanov Alia Linarovna Yarmuhametova Rinat Mukhametovich Zainullin Analysis of the central zone of the retina in patients with diabetic macular edema
description	Aim. To assess morphological changes of retinal layers and optical density of macular pigment in patients with diabetic macular edema (DME) for the diagnostic criterion of pathological process.Materials and methods. 31 patients were divided in two groups. The first group (A) included 19 patients with DME (20 eyes), the second group (B) – 12 patients (20 eyes) without retinal pathology. Both groups were comparable with regard to age. Parameter estimation was conducted with the use of following methods: optical coherence tomography (OCT) of the macular area of the retina; fundus photography with the measurement of macular pigment optical density (MPOD); microperimetry.Results. OCT analysis showed that the inner nuclear and plexiform layers of retina were the most involved in pathological process and revealed significant differences in increase of mean retinal thickness in comparison with the control group. Analysis of MPOD revealed a significant reduction of all parameters in group A compared with the control group. On the basis of microperimetry of the central area of retina in group A light sensitivity indicators were reduced by an average of 9 dB and equaled 9.85 ± 0.09 dB. The analysis showed gross violations of retinal structure and distribution of optical density of macular pigment in patients with DME. Correlation analysis of retinal thickness, functional light sensitivity and optical density of macular pigment traced a strong connection (r = -0.93; p <0.05) between the indices of retinal thickness and MPOD.Conclusions. Diabetic macular edema showed a sharp decrease in optical density of macular pigment determined by deficiency of lutein and zeaxantin. A correlation between quantitative indicator of optical density of macular pigment and area of edema was established. Light sensitivity was significantly reduced in the central part of the retina.
format	article
author	Mukharram Muhtaramovich Bikbov Rinat Rustamovich Fayzrakhmanov Alia Linarovna Yarmuhametova Rinat Mukhametovich Zainullin
author_facet	Mukharram Muhtaramovich Bikbov Rinat Rustamovich Fayzrakhmanov Alia Linarovna Yarmuhametova Rinat Mukhametovich Zainullin
author_sort	Mukharram Muhtaramovich Bikbov
title	Analysis of the central zone of the retina in patients with diabetic macular edema
title_short	Analysis of the central zone of the retina in patients with diabetic macular edema
title_full	Analysis of the central zone of the retina in patients with diabetic macular edema
title_fullStr	Analysis of the central zone of the retina in patients with diabetic macular edema
title_full_unstemmed	Analysis of the central zone of the retina in patients with diabetic macular edema
title_sort	analysis of the central zone of the retina in patients with diabetic macular edema
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/c0a4aa04e70c4287bf8cb2d0bee0b4a5
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Analysis of the central zone of the retina in patients with diabetic macular edema

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