Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations

Abstract Background The FreeStyle Libre (Abbott Laboratories) is a flash glucose monitoring system (FGMS) that measures interstitial glucose concentration (IG). The system is factory‐calibrated, easy to use, inexpensive, and could be useful for monitoring diabetic cats. Objectives To evaluate the an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesca Del Baldo, Federico Fracassi, Jully Pires, Antonio Maria Tardo, Eleonora Malerba, Elisa Manassero, Chen Gilor
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	continuous glucose monitoring system delay diabetes mellitus FreeStyle Libre insulin Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/c0a7ac8d8c564810acbf31e6231a546b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c0a7ac8d8c564810acbf31e6231a546b
record_format	dspace
spelling	oai:doaj.org-article:c0a7ac8d8c564810acbf31e6231a546b2021-11-30T17:01:03ZAccuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations1939-16760891-664010.1111/jvim.16122https://doaj.org/article/c0a7ac8d8c564810acbf31e6231a546b2021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16122https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background The FreeStyle Libre (Abbott Laboratories) is a flash glucose monitoring system (FGMS) that measures interstitial glucose concentration (IG). The system is factory‐calibrated, easy to use, inexpensive, and could be useful for monitoring diabetic cats. Objectives To evaluate the analytical and clinical accuracy of the FGMS in cats and establish the lag‐time between IG and blood glucose concentration (BG). Animals Twenty client‐owned diabetic cats and 7 purpose‐bred healthy cats. Methods Prospective study. Blood glucose concentration was measured using a portable glucose meter validated for use in cats that served as a reference method for IG, as measured by FGMS. In diabetic cats, data were collected for sensor wearing time with different methods of application and accuracy across glycemic ranges. Accuracy was determined by fulfillment of ISO15197:2013 criteria. In healthy cats, lag‐time between IG and BG was established after IV administration of exogenous glucose. Results Good agreement between IG and BG was obtained (r = .93). Analytical accuracy was not achieved, whereas clinical accuracy was demonstrated with 100% of the results in zones A + B of the Parkes consensus error grid analysis. In the immediate 30 minutes after an IV bolus of glucose, when BG was increasing rapidly (approximately 2%/min), IG increased slowly, resulting in a difference of as much as 579 mg/dL, and no positive correlation between BG and IG was found. Conclusions and Clinical Importance The FGMS did not fulfill ISO requirements but is sufficiently accurate for glucose monitoring in cats, while considering the lag between IG and BG during periods of rapid changes in BG.Francesca Del BaldoFederico FracassiJully PiresAntonio Maria TardoEleonora MalerbaElisa ManasseroChen GilorWileyarticlecontinuous glucose monitoring systemdelaydiabetes mellitusFreeStyle LibreinsulinVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1279-1287 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	continuous glucose monitoring system delay diabetes mellitus FreeStyle Libre insulin Veterinary medicine SF600-1100
spellingShingle	continuous glucose monitoring system delay diabetes mellitus FreeStyle Libre insulin Veterinary medicine SF600-1100 Francesca Del Baldo Federico Fracassi Jully Pires Antonio Maria Tardo Eleonora Malerba Elisa Manassero Chen Gilor Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations
description	Abstract Background The FreeStyle Libre (Abbott Laboratories) is a flash glucose monitoring system (FGMS) that measures interstitial glucose concentration (IG). The system is factory‐calibrated, easy to use, inexpensive, and could be useful for monitoring diabetic cats. Objectives To evaluate the analytical and clinical accuracy of the FGMS in cats and establish the lag‐time between IG and blood glucose concentration (BG). Animals Twenty client‐owned diabetic cats and 7 purpose‐bred healthy cats. Methods Prospective study. Blood glucose concentration was measured using a portable glucose meter validated for use in cats that served as a reference method for IG, as measured by FGMS. In diabetic cats, data were collected for sensor wearing time with different methods of application and accuracy across glycemic ranges. Accuracy was determined by fulfillment of ISO15197:2013 criteria. In healthy cats, lag‐time between IG and BG was established after IV administration of exogenous glucose. Results Good agreement between IG and BG was obtained (r = .93). Analytical accuracy was not achieved, whereas clinical accuracy was demonstrated with 100% of the results in zones A + B of the Parkes consensus error grid analysis. In the immediate 30 minutes after an IV bolus of glucose, when BG was increasing rapidly (approximately 2%/min), IG increased slowly, resulting in a difference of as much as 579 mg/dL, and no positive correlation between BG and IG was found. Conclusions and Clinical Importance The FGMS did not fulfill ISO requirements but is sufficiently accurate for glucose monitoring in cats, while considering the lag between IG and BG during periods of rapid changes in BG.
format	article
author	Francesca Del Baldo Federico Fracassi Jully Pires Antonio Maria Tardo Eleonora Malerba Elisa Manassero Chen Gilor
author_facet	Francesca Del Baldo Federico Fracassi Jully Pires Antonio Maria Tardo Eleonora Malerba Elisa Manassero Chen Gilor
author_sort	Francesca Del Baldo
title	Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations
title_short	Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations
title_full	Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations
title_fullStr	Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations
title_full_unstemmed	Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations
title_sort	accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/c0a7ac8d8c564810acbf31e6231a546b
work_keys_str_mv	AT francescadelbaldo accuracyofaflashglucosemonitoringsystemincatsanddeterminationofthetimelagbetweenbloodglucoseandinterstitialglucoseconcentrations AT federicofracassi accuracyofaflashglucosemonitoringsystemincatsanddeterminationofthetimelagbetweenbloodglucoseandinterstitialglucoseconcentrations AT jullypires accuracyofaflashglucosemonitoringsystemincatsanddeterminationofthetimelagbetweenbloodglucoseandinterstitialglucoseconcentrations AT antoniomariatardo accuracyofaflashglucosemonitoringsystemincatsanddeterminationofthetimelagbetweenbloodglucoseandinterstitialglucoseconcentrations AT eleonoramalerba accuracyofaflashglucosemonitoringsystemincatsanddeterminationofthetimelagbetweenbloodglucoseandinterstitialglucoseconcentrations AT elisamanassero accuracyofaflashglucosemonitoringsystemincatsanddeterminationofthetimelagbetweenbloodglucoseandinterstitialglucoseconcentrations AT chengilor accuracyofaflashglucosemonitoringsystemincatsanddeterminationofthetimelagbetweenbloodglucoseandinterstitialglucoseconcentrations
_version_	1718406469360025600

Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations

Ejemplares similares