INPP4B protects from metabolic syndrome and associated disorders

Characterizing mice lacking Inositol Polyphosphate-4-Phosphatase Type II B (INPP4B), Zhang et al. discovered that SREBP1 signaling is activated in livers of Inpp4b −/− males leading to development of NAFLD and insulin resistance. When fed high fat diet, Inpp4b −/− males develop type II diabetes, inf...

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Autores principales:	Manqi Zhang, Yasemin Ceyhan, Elena M. Kaftanovskaya, Judy L. Vasquez, Jean Vacher, Filip K. Knop, Lubov Nathanson, Alexander I. Agoulnik, Michael M. Ittmann, Irina U. Agoulnik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c0aa0d8467f04c44b12025eeec6637fa
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spelling	oai:doaj.org-article:c0aa0d8467f04c44b12025eeec6637fa2021-12-02T16:35:55ZINPP4B protects from metabolic syndrome and associated disorders10.1038/s42003-021-01940-62399-3642https://doaj.org/article/c0aa0d8467f04c44b12025eeec6637fa2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01940-6https://doaj.org/toc/2399-3642Characterizing mice lacking Inositol Polyphosphate-4-Phosphatase Type II B (INPP4B), Zhang et al. discovered that SREBP1 signaling is activated in livers of Inpp4b −/− males leading to development of NAFLD and insulin resistance. When fed high fat diet, Inpp4b −/− males develop type II diabetes, inflammation of adipose tissue, and prostate neoplasia. These findings provide insights into INPP4B protective role from metabolic syndrome.Manqi ZhangYasemin CeyhanElena M. KaftanovskayaJudy L. VasquezJean VacherFilip K. KnopLubov NathansonAlexander I. AgoulnikMichael M. IttmannIrina U. AgoulnikNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Manqi Zhang Yasemin Ceyhan Elena M. Kaftanovskaya Judy L. Vasquez Jean Vacher Filip K. Knop Lubov Nathanson Alexander I. Agoulnik Michael M. Ittmann Irina U. Agoulnik INPP4B protects from metabolic syndrome and associated disorders
description	Characterizing mice lacking Inositol Polyphosphate-4-Phosphatase Type II B (INPP4B), Zhang et al. discovered that SREBP1 signaling is activated in livers of Inpp4b −/− males leading to development of NAFLD and insulin resistance. When fed high fat diet, Inpp4b −/− males develop type II diabetes, inflammation of adipose tissue, and prostate neoplasia. These findings provide insights into INPP4B protective role from metabolic syndrome.
format	article
author	Manqi Zhang Yasemin Ceyhan Elena M. Kaftanovskaya Judy L. Vasquez Jean Vacher Filip K. Knop Lubov Nathanson Alexander I. Agoulnik Michael M. Ittmann Irina U. Agoulnik
author_facet	Manqi Zhang Yasemin Ceyhan Elena M. Kaftanovskaya Judy L. Vasquez Jean Vacher Filip K. Knop Lubov Nathanson Alexander I. Agoulnik Michael M. Ittmann Irina U. Agoulnik
author_sort	Manqi Zhang
title	INPP4B protects from metabolic syndrome and associated disorders
title_short	INPP4B protects from metabolic syndrome and associated disorders
title_full	INPP4B protects from metabolic syndrome and associated disorders
title_fullStr	INPP4B protects from metabolic syndrome and associated disorders
title_full_unstemmed	INPP4B protects from metabolic syndrome and associated disorders
title_sort	inpp4b protects from metabolic syndrome and associated disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0aa0d8467f04c44b12025eeec6637fa
work_keys_str_mv	AT manqizhang inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT yaseminceyhan inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT elenamkaftanovskaya inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT judylvasquez inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT jeanvacher inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT filipkknop inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT lubovnathanson inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT alexanderiagoulnik inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT michaelmittmann inpp4bprotectsfrommetabolicsyndromeandassociateddisorders AT irinauagoulnik inpp4bprotectsfrommetabolicsyndromeandassociateddisorders
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INPP4B protects from metabolic syndrome and associated disorders

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