Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z.

Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z.

Differential positioning of the histone variant H2A.Z in a p53 dependent manner was shown to regulate p21 transcription. Whether H2A.Z is involved in p21 activity in the absence of p53 is not known. The p21 gene is repressed in estrogen receptor (ER) negative cell lines that are p53-/- and hormone i...

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Autores principales: Luca Bellucci, Mathieu Dalvai, Silvia Kocanova, Fatima Moutahir, Kerstin Bystricky
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/c0ab82d03589495dbb95fd7f58f859e3
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