Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models

The effects of anesthetics on cancer metastasis are largely unknown. Here, the authors show in two preclinical mouse models that surgical resection of primary tumours under anesthesia with sevoflurane leads to more lung metastases than with propofol and that such distinct effects are associated with...

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Autores principales:	Ru Li, Yujie Huang, Jun Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0ae4d5cd61746c8a1f6a34feae7f781
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spelling	oai:doaj.org-article:c0ae4d5cd61746c8a1f6a34feae7f7812021-12-02T17:32:25ZDistinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models10.1038/s41467-019-14065-62041-1723https://doaj.org/article/c0ae4d5cd61746c8a1f6a34feae7f7812020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14065-6https://doaj.org/toc/2041-1723The effects of anesthetics on cancer metastasis are largely unknown. Here, the authors show in two preclinical mouse models that surgical resection of primary tumours under anesthesia with sevoflurane leads to more lung metastases than with propofol and that such distinct effects are associated with change of cytokines and modulation of myeloid cells in the lung.Ru LiYujie HuangJun LinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ru Li Yujie Huang Jun Lin Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models
description	The effects of anesthetics on cancer metastasis are largely unknown. Here, the authors show in two preclinical mouse models that surgical resection of primary tumours under anesthesia with sevoflurane leads to more lung metastases than with propofol and that such distinct effects are associated with change of cytokines and modulation of myeloid cells in the lung.
format	article
author	Ru Li Yujie Huang Jun Lin
author_facet	Ru Li Yujie Huang Jun Lin
author_sort	Ru Li
title	Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models
title_short	Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models
title_full	Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models
title_fullStr	Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models
title_full_unstemmed	Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models
title_sort	distinct effects of general anesthetics on lung metastasis mediated by il-6/jak/stat3 pathway in mouse models
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c0ae4d5cd61746c8a1f6a34feae7f781
work_keys_str_mv	AT ruli distincteffectsofgeneralanestheticsonlungmetastasismediatedbyil6jakstat3pathwayinmousemodels AT yujiehuang distincteffectsofgeneralanestheticsonlungmetastasismediatedbyil6jakstat3pathwayinmousemodels AT junlin distincteffectsofgeneralanestheticsonlungmetastasismediatedbyil6jakstat3pathwayinmousemodels
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Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models

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