Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles

Abstract Background This cardiovascular magnetic resonance (CMR) study investigates the impact of trabeculae and papillary muscles (TPM) on diastolic function parameters by differentiation of the time-volume curve. Differentiation causes additional problems, which is overcome by standardization. Met...

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Autores principales:	Bjoern P. Schoennagel, Kai Müllerleile, Enver Tahir, Jitka Starekova, Regine Grosse, Jin Yamamura, Peter Bannas, Gerhard Adam, Roland Fischer
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Diastolic function Trabeculae and papillary muscles Cardiovascular magnetic resonance Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/c0ae9dd9eacb40eb83996ca944966e39
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spelling	oai:doaj.org-article:c0ae9dd9eacb40eb83996ca944966e392021-11-07T12:14:40ZInsights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles10.1186/s13244-021-01104-41869-4101https://doaj.org/article/c0ae9dd9eacb40eb83996ca944966e392021-11-01T00:00:00Zhttps://doi.org/10.1186/s13244-021-01104-4https://doaj.org/toc/1869-4101Abstract Background This cardiovascular magnetic resonance (CMR) study investigates the impact of trabeculae and papillary muscles (TPM) on diastolic function parameters by differentiation of the time-volume curve. Differentiation causes additional problems, which is overcome by standardization. Methods Cine steady-state free-precession imaging at 1.5 T was performed in 40 healthy volunteers stratified for age (age range 7–78y). LV time-volume curves were assessed by software-assisted delineation of endocardial contours from short axis slices applying two different methods: (1) inclusion of TPM into the myocardium and (2) inclusion of TPM into the LV cavity blood volume. Diastolic function was assessed from the differentiated time-volume curves defining the early and atrial peaks, their filling rates, filling volumes, and further dedicated diastolic measures, respectively. Results Only inclusion of TPM into the myocardium allowed precise assessment of early and atrial peak filling rates (EPFR, APFR) with clear distinction of EPFR and APFR expressed by the minimum between the early and atrial peak (EAmin) (100% vs. 36% for EAmin < 0.8). Prediction of peak filling rate ratios (PFRR) and filling volume ratios (FVR) by age was superior with inclusion of TPM into the myocardium compared to inclusion into the blood pool (r 2 = 0.85 vs. r 2 = 0.56 and r 2 = 0.89 vs. r 2 = 0.66). Standardization problems were overcome by the introduction of a third phase (mid-diastole, apart from diastole and systole) and fitting of the early and atrial peaks in the differentiated time-volume curve. Conclusions Only LV volumetry with inclusion of TPM into the myocardium allows precise determination of diastolic measures and prevents methodological artifacts.Bjoern P. SchoennagelKai MüllerleileEnver TahirJitka StarekovaRegine GrosseJin YamamuraPeter BannasGerhard AdamRoland FischerSpringerOpenarticleDiastolic functionTrabeculae and papillary musclesCardiovascular magnetic resonanceMedical physics. Medical radiology. Nuclear medicineR895-920ENInsights into Imaging, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diastolic function Trabeculae and papillary muscles Cardiovascular magnetic resonance Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Diastolic function Trabeculae and papillary muscles Cardiovascular magnetic resonance Medical physics. Medical radiology. Nuclear medicine R895-920 Bjoern P. Schoennagel Kai Müllerleile Enver Tahir Jitka Starekova Regine Grosse Jin Yamamura Peter Bannas Gerhard Adam Roland Fischer Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles
description	Abstract Background This cardiovascular magnetic resonance (CMR) study investigates the impact of trabeculae and papillary muscles (TPM) on diastolic function parameters by differentiation of the time-volume curve. Differentiation causes additional problems, which is overcome by standardization. Methods Cine steady-state free-precession imaging at 1.5 T was performed in 40 healthy volunteers stratified for age (age range 7–78y). LV time-volume curves were assessed by software-assisted delineation of endocardial contours from short axis slices applying two different methods: (1) inclusion of TPM into the myocardium and (2) inclusion of TPM into the LV cavity blood volume. Diastolic function was assessed from the differentiated time-volume curves defining the early and atrial peaks, their filling rates, filling volumes, and further dedicated diastolic measures, respectively. Results Only inclusion of TPM into the myocardium allowed precise assessment of early and atrial peak filling rates (EPFR, APFR) with clear distinction of EPFR and APFR expressed by the minimum between the early and atrial peak (EAmin) (100% vs. 36% for EAmin < 0.8). Prediction of peak filling rate ratios (PFRR) and filling volume ratios (FVR) by age was superior with inclusion of TPM into the myocardium compared to inclusion into the blood pool (r 2 = 0.85 vs. r 2 = 0.56 and r 2 = 0.89 vs. r 2 = 0.66). Standardization problems were overcome by the introduction of a third phase (mid-diastole, apart from diastole and systole) and fitting of the early and atrial peaks in the differentiated time-volume curve. Conclusions Only LV volumetry with inclusion of TPM into the myocardium allows precise determination of diastolic measures and prevents methodological artifacts.
format	article
author	Bjoern P. Schoennagel Kai Müllerleile Enver Tahir Jitka Starekova Regine Grosse Jin Yamamura Peter Bannas Gerhard Adam Roland Fischer
author_facet	Bjoern P. Schoennagel Kai Müllerleile Enver Tahir Jitka Starekova Regine Grosse Jin Yamamura Peter Bannas Gerhard Adam Roland Fischer
author_sort	Bjoern P. Schoennagel
title	Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles
title_short	Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles
title_full	Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles
title_fullStr	Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles
title_full_unstemmed	Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles
title_sort	insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/c0ae9dd9eacb40eb83996ca944966e39
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Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles

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