Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

CXCR2 antagonism has been shown to be anti-arthritic, but anti-chemokine therapies usually fail in the clinic owing to redundancy in chemokine-receptor interactions. Here the authors develop single-chain antibodies with multiple chemokine specificities to achieve high affinity and broad specificity...

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Autores principales:	Alessandro Angelini, Yoshishige Miyabe, Daniel Newsted, Byron H. Kwan, Chie Miyabe, Ryan L. Kelly, Misha N. Jamy, Andrew D. Luster, K. Dane Wittrup
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0b1123a348f40e095ceb7693a617ee1
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spelling	oai:doaj.org-article:c0b1123a348f40e095ceb7693a617ee12021-12-02T15:34:38ZDirected evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis10.1038/s41467-018-03687-x2041-1723https://doaj.org/article/c0b1123a348f40e095ceb7693a617ee12018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03687-xhttps://doaj.org/toc/2041-1723CXCR2 antagonism has been shown to be anti-arthritic, but anti-chemokine therapies usually fail in the clinic owing to redundancy in chemokine-receptor interactions. Here the authors develop single-chain antibodies with multiple chemokine specificities to achieve high affinity and broad specificity to mouse and human CXC chemokines with efficacy in a K/BxN serum transfer model of arthritis.Alessandro AngeliniYoshishige MiyabeDaniel NewstedByron H. KwanChie MiyabeRyan L. KellyMisha N. JamyAndrew D. LusterK. Dane WittrupNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Angelini Yoshishige Miyabe Daniel Newsted Byron H. Kwan Chie Miyabe Ryan L. Kelly Misha N. Jamy Andrew D. Luster K. Dane Wittrup Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
description	CXCR2 antagonism has been shown to be anti-arthritic, but anti-chemokine therapies usually fail in the clinic owing to redundancy in chemokine-receptor interactions. Here the authors develop single-chain antibodies with multiple chemokine specificities to achieve high affinity and broad specificity to mouse and human CXC chemokines with efficacy in a K/BxN serum transfer model of arthritis.
format	article
author	Alessandro Angelini Yoshishige Miyabe Daniel Newsted Byron H. Kwan Chie Miyabe Ryan L. Kelly Misha N. Jamy Andrew D. Luster K. Dane Wittrup
author_facet	Alessandro Angelini Yoshishige Miyabe Daniel Newsted Byron H. Kwan Chie Miyabe Ryan L. Kelly Misha N. Jamy Andrew D. Luster K. Dane Wittrup
author_sort	Alessandro Angelini
title	Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
title_short	Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
title_full	Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
title_fullStr	Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
title_full_unstemmed	Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
title_sort	directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c0b1123a348f40e095ceb7693a617ee1
work_keys_str_mv	AT alessandroangelini directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis AT yoshishigemiyabe directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis AT danielnewsted directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis AT byronhkwan directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis AT chiemiyabe directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis AT ryanlkelly directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis AT mishanjamy directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis AT andrewdluster directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis AT kdanewittrup directedevolutionofbroadlycrossreactivechemokineblockingantibodiesefficaciousinarthritis
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Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

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