The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) causes, besides the primary brain injury, a secondary brain injury (SBI), which is induced, amongst other things, by oxidative stress (OS) and inflammation, determining the patient’s outcome. This study aims to assess the impact of OS in plasma and cerebros...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c0b54e7433884d33a91574c6ed48a2f8 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c0b54e7433884d33a91574c6ed48a2f8 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c0b54e7433884d33a91574c6ed48a2f82021-11-25T16:52:49ZThe Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage10.3390/biom111116152218-273Xhttps://doaj.org/article/c0b54e7433884d33a91574c6ed48a2f82021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1615https://doaj.org/toc/2218-273XSpontaneous intracerebral hemorrhage (ICH) causes, besides the primary brain injury, a secondary brain injury (SBI), which is induced, amongst other things, by oxidative stress (OS) and inflammation, determining the patient’s outcome. This study aims to assess the impact of OS in plasma and cerebrospinal fluid (CSF) on clinical outcomes in patients with ICH. A total of 19 ICH (volume > 30 cc) patients and 29 control patients were included. From day one until seven, blood and CSF samples were obtained, and ICH volume was calculated. OS markers, like malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-sulfhydryl (GSH), and the total antioxidant status (TAS) were measured. Clinical data on treatment and outcome were determined. Patients with mRS ≤ 4 showed significantly elevated SOD and GSH-Px levels in plasma compared to patients with poor CO (<i>p</i> = 0.004; <i>p</i> = 0.002). Initial increased TAS in plasma and increased MDA in CSF were linked to an unfavorable outcome after six months (<i>p</i> = 0.06, r = 0.45; <i>p</i> = 0.05, r = 0.44). A higher ICH volume was associated with a worse outcome at week six (<i>p</i> = 0.04, r = 0.47). OS plays a significant role in SBI. Larger ICHs, elevated MDA in CSF, and TAS in plasma were associated with a detrimental outcome, whereas higher plasma-SOD and -GSH-Px were associated with a favorable outcome.Julia Masomi-BornwasserElena KurzChristina FrenzJan SchmittDominik M. A. WespJochem KönigJohannes LotzFlorian RingelThomas KerzHarald KrenzlinNaureen KericMDPI AGarticleoxidative stressintracerebral hemorrhageneurological outcomeoxidative stress markerscerebrospinal fluidMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1615, p 1615 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
oxidative stress intracerebral hemorrhage neurological outcome oxidative stress markers cerebrospinal fluid Microbiology QR1-502 |
| spellingShingle |
oxidative stress intracerebral hemorrhage neurological outcome oxidative stress markers cerebrospinal fluid Microbiology QR1-502 Julia Masomi-Bornwasser Elena Kurz Christina Frenz Jan Schmitt Dominik M. A. Wesp Jochem König Johannes Lotz Florian Ringel Thomas Kerz Harald Krenzlin Naureen Keric The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| description |
Spontaneous intracerebral hemorrhage (ICH) causes, besides the primary brain injury, a secondary brain injury (SBI), which is induced, amongst other things, by oxidative stress (OS) and inflammation, determining the patient’s outcome. This study aims to assess the impact of OS in plasma and cerebrospinal fluid (CSF) on clinical outcomes in patients with ICH. A total of 19 ICH (volume > 30 cc) patients and 29 control patients were included. From day one until seven, blood and CSF samples were obtained, and ICH volume was calculated. OS markers, like malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-sulfhydryl (GSH), and the total antioxidant status (TAS) were measured. Clinical data on treatment and outcome were determined. Patients with mRS ≤ 4 showed significantly elevated SOD and GSH-Px levels in plasma compared to patients with poor CO (<i>p</i> = 0.004; <i>p</i> = 0.002). Initial increased TAS in plasma and increased MDA in CSF were linked to an unfavorable outcome after six months (<i>p</i> = 0.06, r = 0.45; <i>p</i> = 0.05, r = 0.44). A higher ICH volume was associated with a worse outcome at week six (<i>p</i> = 0.04, r = 0.47). OS plays a significant role in SBI. Larger ICHs, elevated MDA in CSF, and TAS in plasma were associated with a detrimental outcome, whereas higher plasma-SOD and -GSH-Px were associated with a favorable outcome. |
| format |
article |
| author |
Julia Masomi-Bornwasser Elena Kurz Christina Frenz Jan Schmitt Dominik M. A. Wesp Jochem König Johannes Lotz Florian Ringel Thomas Kerz Harald Krenzlin Naureen Keric |
| author_facet |
Julia Masomi-Bornwasser Elena Kurz Christina Frenz Jan Schmitt Dominik M. A. Wesp Jochem König Johannes Lotz Florian Ringel Thomas Kerz Harald Krenzlin Naureen Keric |
| author_sort |
Julia Masomi-Bornwasser |
| title |
The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_short |
The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_full |
The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_fullStr |
The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_full_unstemmed |
The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage |
| title_sort |
influence of oxidative stress on neurological outcomes in spontaneous intracerebral hemorrhage |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/c0b54e7433884d33a91574c6ed48a2f8 |
| work_keys_str_mv |
AT juliamasomibornwasser theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT elenakurz theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT christinafrenz theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT janschmitt theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT dominikmawesp theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT jochemkonig theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT johanneslotz theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT florianringel theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT thomaskerz theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT haraldkrenzlin theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT naureenkeric theinfluenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT juliamasomibornwasser influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT elenakurz influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT christinafrenz influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT janschmitt influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT dominikmawesp influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT jochemkonig influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT johanneslotz influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT florianringel influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT thomaskerz influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT haraldkrenzlin influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage AT naureenkeric influenceofoxidativestressonneurologicaloutcomesinspontaneousintracerebralhemorrhage |
| _version_ |
1718412920093671424 |