Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury

Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury

Wenshuo Wang,1,* Huan Liu,1,* Yuntao Lu,1,* Xiaole Wang,2,* Bohan Zhang,3 Shuo Cong,1 Yun Zhao,1 Minbiao Ji,3 Hongyue Tao,4 Lai Wei1,5 1Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China; 2Department of Radiology, Second People’s Hospital of Nanton...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Wang W, Liu H, Lu YT, Wang X, Zhang B, Cong S, Zhao Y, Ji M, Tao H, Wei L
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
steady release
porous structure
biocompatibility
biodegeneration.
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/c0b69ac54e57479492c44ed49cb00e0a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c0b69ac54e57479492c44ed49cb00e0a
record_format dspace
spelling oai:doaj.org-article:c0b69ac54e57479492c44ed49cb00e0a2021-12-02T06:27:58ZControlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury1178-2013https://doaj.org/article/c0b69ac54e57479492c44ed49cb00e0a2019-01-01T00:00:00Zhttps://www.dovepress.com/controlled-releasing-hydrogen-sulfide-donor-based-on-dual-modal-iron-o-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Wenshuo Wang,1,* Huan Liu,1,* Yuntao Lu,1,* Xiaole Wang,2,* Bohan Zhang,3 Shuo Cong,1 Yun Zhao,1 Minbiao Ji,3 Hongyue Tao,4 Lai Wei1,5 1Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China; 2Department of Radiology, Second People’s Hospital of Nantong City, Nantong 226002, Jiangsu, China; 3State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China; 4Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200040, China; 5Department of Cardiac Surgery, Shanghai Public Health Clincal Center, Shanghai 201508, China *These authors contributed equally to this work Background: Hydrogen sulfide (H2S) has shown promising therapeutic benefits in reversing a variety of pathophysiological processes in cardiovascular system, including myocardial ischemia–reperfusion (IR) injury. However, the achievement of controlled and sustained release of H2S has been a technical bottleneck that limits the clinical application of the gas molecule.Methods: The current study describes the development of mesoporous iron oxide nanoparticles (MIONs) which were loaded with diallyl trisulfide (DATS), a H2S donor compound, and calibrated by stimulated Raman scattering/transient absorption.Results: The synthesized MIONs were characterized with excellent mesoporosity and a narrow size distribution, which enabled them to slow down the release of H2S to a suitable rate and prolong the plateau period. The controlled-release feature of DATS-MIONs resulted in little adverse effect both in vitro and in vivo, and their protective effect on the heart tissue that underwent IR injury was observed in the mouse model of myocardial ischemia. The rapid biodegradation of DATS-MIONs was induced by Kupffer cells, which were specialized macrophages located in the liver and caused limited hepatic metabolic burden.Conclusion: The sustained-release pattern and excellent biocompatibility make DATS-MIONs a promising H2S donor for research and medical purposes. Keywords: steady release, porous structure, biocompatibility, biodegenerationWang WLiu HLu YTWang XZhang BCong SZhao YJi MTao HWei LDove Medical Pressarticlesteady releaseporous structurebiocompatibilitybiodegeneration.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 875-888 (2019)
institution DOAJ
collection DOAJ
language EN
topic steady release
porous structure
biocompatibility
biodegeneration.
Medicine (General)
R5-920
spellingShingle steady release
porous structure
biocompatibility
biodegeneration.
Medicine (General)
R5-920
Wang W
Liu H
Lu YT
Wang X
Zhang B
Cong S
Zhao Y
Ji M
Tao H
Wei L
Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury
description Wenshuo Wang,1,* Huan Liu,1,* Yuntao Lu,1,* Xiaole Wang,2,* Bohan Zhang,3 Shuo Cong,1 Yun Zhao,1 Minbiao Ji,3 Hongyue Tao,4 Lai Wei1,5 1Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China; 2Department of Radiology, Second People’s Hospital of Nantong City, Nantong 226002, Jiangsu, China; 3State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China; 4Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200040, China; 5Department of Cardiac Surgery, Shanghai Public Health Clincal Center, Shanghai 201508, China *These authors contributed equally to this work Background: Hydrogen sulfide (H2S) has shown promising therapeutic benefits in reversing a variety of pathophysiological processes in cardiovascular system, including myocardial ischemia–reperfusion (IR) injury. However, the achievement of controlled and sustained release of H2S has been a technical bottleneck that limits the clinical application of the gas molecule.Methods: The current study describes the development of mesoporous iron oxide nanoparticles (MIONs) which were loaded with diallyl trisulfide (DATS), a H2S donor compound, and calibrated by stimulated Raman scattering/transient absorption.Results: The synthesized MIONs were characterized with excellent mesoporosity and a narrow size distribution, which enabled them to slow down the release of H2S to a suitable rate and prolong the plateau period. The controlled-release feature of DATS-MIONs resulted in little adverse effect both in vitro and in vivo, and their protective effect on the heart tissue that underwent IR injury was observed in the mouse model of myocardial ischemia. The rapid biodegradation of DATS-MIONs was induced by Kupffer cells, which were specialized macrophages located in the liver and caused limited hepatic metabolic burden.Conclusion: The sustained-release pattern and excellent biocompatibility make DATS-MIONs a promising H2S donor for research and medical purposes. Keywords: steady release, porous structure, biocompatibility, biodegeneration
format article
author Wang W
Liu H
Lu YT
Wang X
Zhang B
Cong S
Zhao Y
Ji M
Tao H
Wei L
author_facet Wang W
Liu H
Lu YT
Wang X
Zhang B
Cong S
Zhao Y
Ji M
Tao H
Wei L
author_sort Wang W
title Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury
title_short Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury
title_full Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury
title_fullStr Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury
title_full_unstemmed Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury
title_sort controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia–reperfusion injury
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/c0b69ac54e57479492c44ed49cb00e0a
work_keys_str_mv AT wangw controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT liuh controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT luyt controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT wangx controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT zhangb controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT congs controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT zhaoy controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT jim controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT taoh controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
AT weil controlledreleasinghydrogensulfidedonorbasedondualmodalironoxidenanoparticlesprotectsmyocardialtissuefromischemiandashreperfusioninjury
_version_ 1718399898189037568

Ejemplares similares