Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome

77 male patients (mean age 47?7.4 years) without ischaemic heart disease were tested for metabolic syndrome factors, risk for developmentof type 2 diabetes mellitus (T2DM) according to FINDRISK questionnaire, following with assessment of intracellularmetabolism parameters of neutrophils. Increased r...

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Autores principales:	Andrey Evgen'evich Kratnov, Elena Nikolaevna Lopatnikova, Alexander Andreevich Kratnov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	metabolic syndrome diabetes mellitus type 2 neutrophils reactive oxygen species antioxidants Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c0b703a51cd4415e91d10fab7164fd96
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spelling	oai:doaj.org-article:c0b703a51cd4415e91d10fab7164fd962021-11-14T09:00:17ZIntracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome2072-03512072-037810.14341/2072-0351-5512https://doaj.org/article/c0b703a51cd4415e91d10fab7164fd962012-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5512https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-037877 male patients (mean age 47?7.4 years) without ischaemic heart disease were tested for metabolic syndrome factors, risk for developmentof type 2 diabetes mellitus (T2DM) according to FINDRISK questionnaire, following with assessment of intracellularmetabolism parameters of neutrophils. Increased risk for T2DM positively correlated in these patients with myeloperoxidase activity,level of hydrogen peroxide within neutrophils and BMI. We observed elevation of oxygen-dependent metabolism in neutrophils formpatients with morbid obesity, accompanied with decrease in antioxidant factors, which is suggestive of oxidative stress.Andrey Evgen'evich KratnovElena Nikolaevna LopatnikovaAlexander Andreevich KratnovEndocrinology Research Centrearticlemetabolic syndromediabetes mellitus type 2neutrophilsreactive oxygen speciesantioxidantsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 2, Pp 13-16 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	metabolic syndrome diabetes mellitus type 2 neutrophils reactive oxygen species antioxidants Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	metabolic syndrome diabetes mellitus type 2 neutrophils reactive oxygen species antioxidants Nutritional diseases. Deficiency diseases RC620-627 Andrey Evgen'evich Kratnov Elena Nikolaevna Lopatnikova Alexander Andreevich Kratnov Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
description	77 male patients (mean age 47?7.4 years) without ischaemic heart disease were tested for metabolic syndrome factors, risk for developmentof type 2 diabetes mellitus (T2DM) according to FINDRISK questionnaire, following with assessment of intracellularmetabolism parameters of neutrophils. Increased risk for T2DM positively correlated in these patients with myeloperoxidase activity,level of hydrogen peroxide within neutrophils and BMI. We observed elevation of oxygen-dependent metabolism in neutrophils formpatients with morbid obesity, accompanied with decrease in antioxidant factors, which is suggestive of oxidative stress.
format	article
author	Andrey Evgen'evich Kratnov Elena Nikolaevna Lopatnikova Alexander Andreevich Kratnov
author_facet	Andrey Evgen'evich Kratnov Elena Nikolaevna Lopatnikova Alexander Andreevich Kratnov
author_sort	Andrey Evgen'evich Kratnov
title	Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
title_short	Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
title_full	Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
title_fullStr	Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
title_full_unstemmed	Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
title_sort	intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/c0b703a51cd4415e91d10fab7164fd96
work_keys_str_mv	AT andreyevgenevichkratnov intracellularmetabolismofneutrophilsandriskfordevelopmentoftype2diabetesmellitusinpatientswithmetabolicsyndrome AT elenanikolaevnalopatnikova intracellularmetabolismofneutrophilsandriskfordevelopmentoftype2diabetesmellitusinpatientswithmetabolicsyndrome AT alexanderandreevichkratnov intracellularmetabolismofneutrophilsandriskfordevelopmentoftype2diabetesmellitusinpatientswithmetabolicsyndrome
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Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome

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