A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment

Abstract Previous, we established a novel therapeutic approach to tumour of cryo-thermal therapy, which can induce durable anti-tumour memory immunity mediated by CD4+ T cell, and contribute to prolonged survival in B16F10 murine melanoma model and 4T1 murine mammary carcinoma. It has become apparen...

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Autores principales:	Shengguo Jia, Wentao Li, Ping Liu, Lisa X. Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0bac1a3e06a4baa95e9f477e9c39969
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spelling	oai:doaj.org-article:c0bac1a3e06a4baa95e9f477e9c399692021-12-02T15:09:14ZA role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment10.1038/s41598-019-49734-52045-2322https://doaj.org/article/c0bac1a3e06a4baa95e9f477e9c399692019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-49734-5https://doaj.org/toc/2045-2322Abstract Previous, we established a novel therapeutic approach to tumour of cryo-thermal therapy, which can induce durable anti-tumour memory immunity mediated by CD4+ T cell, and contribute to prolonged survival in B16F10 murine melanoma model and 4T1 murine mammary carcinoma. It has become apparent that innate immune cells are involved in the regulation of adaptive T cell immunity. Our previous studies revealed that cryo-thermal therapy induced M1 macrophage polarization and DCs maturation were required for the shaping of systemic long-lived T cell mediated anti-tumour memory immunity. Eosinophils are multifunctional innate effector cells and there is lack of knowledge on the role of eosinophils in cryo-thermal-induced anti-tumour immunity. This study revealed that cryo-thermal therapy activated eosinophils in spleen at early stage following the treatment. Furthermore, cryo-thermal-activated eosinophils exerted versatile immunologic regulation from innate immunity to anti-tumour adaptive immunity, such as M1 macrophage polarization, DCs maturation, differentiation of CD4-CTL subtypes and enhanced cytotoxicity of CD8+ T cells. Our study indicated that the cryo-thermal-activated eosinophils was essential for the shaping of durable anti-tumour memory immunity. Thus, our results present a new concept for eosinophils mediated anti-tumour immunity after cryo-thermal therapy.Shengguo JiaWentao LiPing LiuLisa X. XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shengguo Jia Wentao Li Ping Liu Lisa X. Xu A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment
description	Abstract Previous, we established a novel therapeutic approach to tumour of cryo-thermal therapy, which can induce durable anti-tumour memory immunity mediated by CD4+ T cell, and contribute to prolonged survival in B16F10 murine melanoma model and 4T1 murine mammary carcinoma. It has become apparent that innate immune cells are involved in the regulation of adaptive T cell immunity. Our previous studies revealed that cryo-thermal therapy induced M1 macrophage polarization and DCs maturation were required for the shaping of systemic long-lived T cell mediated anti-tumour memory immunity. Eosinophils are multifunctional innate effector cells and there is lack of knowledge on the role of eosinophils in cryo-thermal-induced anti-tumour immunity. This study revealed that cryo-thermal therapy activated eosinophils in spleen at early stage following the treatment. Furthermore, cryo-thermal-activated eosinophils exerted versatile immunologic regulation from innate immunity to anti-tumour adaptive immunity, such as M1 macrophage polarization, DCs maturation, differentiation of CD4-CTL subtypes and enhanced cytotoxicity of CD8+ T cells. Our study indicated that the cryo-thermal-activated eosinophils was essential for the shaping of durable anti-tumour memory immunity. Thus, our results present a new concept for eosinophils mediated anti-tumour immunity after cryo-thermal therapy.
format	article
author	Shengguo Jia Wentao Li Ping Liu Lisa X. Xu
author_facet	Shengguo Jia Wentao Li Ping Liu Lisa X. Xu
author_sort	Shengguo Jia
title	A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment
title_short	A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment
title_full	A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment
title_fullStr	A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment
title_full_unstemmed	A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment
title_sort	role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c0bac1a3e06a4baa95e9f477e9c39969
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A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment

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