S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis

S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis

S-nitrosylation can influence many pathophysiological processes. Here the authors show that the coupling efficiency of GNAI2 with CXCR5 is enhanced by S-nitrosylation of GNAI2, leading to Hippo-YAP dysfunction in endothelium, and plays a role in diabetes-accelerated atherosclerosis.

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Autores principales: Meng-Lin Chao, Shanshan Luo, Chao Zhang, Xuechun Zhou, Miao Zhou, Junyan Wang, Chuiyu Kong, Jiyu Chen, Zhe Lin, Xin Tang, Shixiu Sun, Xinlong Tang, Hongshan Chen, Hong Wang, Dongjin Wang, Jin-Peng Sun, Yi Han, Liping Xie, Yong Ji
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c0bb46778ed84b0794e0ffec175854d0
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spelling oai:doaj.org-article:c0bb46778ed84b0794e0ffec175854d02021-12-02T16:17:53ZS-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis10.1038/s41467-021-24736-y2041-1723https://doaj.org/article/c0bb46778ed84b0794e0ffec175854d02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24736-yhttps://doaj.org/toc/2041-1723S-nitrosylation can influence many pathophysiological processes. Here the authors show that the coupling efficiency of GNAI2 with CXCR5 is enhanced by S-nitrosylation of GNAI2, leading to Hippo-YAP dysfunction in endothelium, and plays a role in diabetes-accelerated atherosclerosis.Meng-Lin ChaoShanshan LuoChao ZhangXuechun ZhouMiao ZhouJunyan WangChuiyu KongJiyu ChenZhe LinXin TangShixiu SunXinlong TangHongshan ChenHong WangDongjin WangJin-Peng SunYi HanLiping XieYong JiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Meng-Lin Chao
Shanshan Luo
Chao Zhang
Xuechun Zhou
Miao Zhou
Junyan Wang
Chuiyu Kong
Jiyu Chen
Zhe Lin
Xin Tang
Shixiu Sun
Xinlong Tang
Hongshan Chen
Hong Wang
Dongjin Wang
Jin-Peng Sun
Yi Han
Liping Xie
Yong Ji
S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis
description S-nitrosylation can influence many pathophysiological processes. Here the authors show that the coupling efficiency of GNAI2 with CXCR5 is enhanced by S-nitrosylation of GNAI2, leading to Hippo-YAP dysfunction in endothelium, and plays a role in diabetes-accelerated atherosclerosis.
format article
author Meng-Lin Chao
Shanshan Luo
Chao Zhang
Xuechun Zhou
Miao Zhou
Junyan Wang
Chuiyu Kong
Jiyu Chen
Zhe Lin
Xin Tang
Shixiu Sun
Xinlong Tang
Hongshan Chen
Hong Wang
Dongjin Wang
Jin-Peng Sun
Yi Han
Liping Xie
Yong Ji
author_facet Meng-Lin Chao
Shanshan Luo
Chao Zhang
Xuechun Zhou
Miao Zhou
Junyan Wang
Chuiyu Kong
Jiyu Chen
Zhe Lin
Xin Tang
Shixiu Sun
Xinlong Tang
Hongshan Chen
Hong Wang
Dongjin Wang
Jin-Peng Sun
Yi Han
Liping Xie
Yong Ji
author_sort Meng-Lin Chao
title S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis
title_short S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis
title_full S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis
title_fullStr S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis
title_full_unstemmed S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis
title_sort s-nitrosylation-mediated coupling of g-protein alpha-2 with cxcr5 induces hippo/yap-dependent diabetes-accelerated atherosclerosis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c0bb46778ed84b0794e0ffec175854d0
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