Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis

Abstract Current descriptions of retinal thickness across normal age cohorts are mostly limited to global analyses, thus overlooking spatial variation across the retina and limiting spatial analyses of retinal and optic nerve disease. This retrospective cross-sectional study uses location-specific c...

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Autores principales:	Matt Trinh, Vincent Khou, Barbara Zangerl, Michael Kalloniatis, Lisa Nivison-Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0bbb1446f224ea2a479f4eed6854cdf
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spelling	oai:doaj.org-article:c0bbb1446f224ea2a479f4eed6854cdf2021-12-02T15:23:09ZModelling normal age-related changes in individual retinal layers using location-specific OCT analysis10.1038/s41598-020-79424-62045-2322https://doaj.org/article/c0bbb1446f224ea2a479f4eed6854cdf2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79424-6https://doaj.org/toc/2045-2322Abstract Current descriptions of retinal thickness across normal age cohorts are mostly limited to global analyses, thus overlooking spatial variation across the retina and limiting spatial analyses of retinal and optic nerve disease. This retrospective cross-sectional study uses location-specific cluster analysis of 8 × 8 macular average grid-wise thicknesses to quantify topographical patterns and rates of normal, age-related changes in all individual retinal layers of 253 eyes of 253 participants across various age cohorts (n = 23–69 eyes per decade). Most retinal layers had concentric spatial cluster patterns except the retinal nerve fibre layer (RNFL) which displayed a nasal, asymmetric radial pattern. Age-related thickness decline mostly occurred after the late 4th decade, described by quadratic regression models. The ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer nuclear layer + Henle’s fibre layer (ONL+HFL) were significantly associated with age (p < 0.0001 to < 0.05), demonstrating similar rates of thickness decline (mean pooled slope = − 0.07 µm/year), while the IS/OS had lesser mean pooled thickness slopes for all clusters (− 0.04 µm/year). The RNFL, OPL, and RPE exhibited no significant age-related thickness change, and the RNFL were significantly associated with sex. Analysis using spatial clusters compared to the ETDRS sectors revealed more extensive spatial definition and less variability in the former method. These spatially defined, clustered normative data and age-correction functions provide an accessible method of retinal thickness analysis with more spatial detail and less variability than the ETDRS sectors, potentially aiding the diagnosis and monitoring of retinal and optic nerve disease.Matt TrinhVincent KhouBarbara ZangerlMichael KalloniatisLisa Nivison-SmithNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matt Trinh Vincent Khou Barbara Zangerl Michael Kalloniatis Lisa Nivison-Smith Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis
description	Abstract Current descriptions of retinal thickness across normal age cohorts are mostly limited to global analyses, thus overlooking spatial variation across the retina and limiting spatial analyses of retinal and optic nerve disease. This retrospective cross-sectional study uses location-specific cluster analysis of 8 × 8 macular average grid-wise thicknesses to quantify topographical patterns and rates of normal, age-related changes in all individual retinal layers of 253 eyes of 253 participants across various age cohorts (n = 23–69 eyes per decade). Most retinal layers had concentric spatial cluster patterns except the retinal nerve fibre layer (RNFL) which displayed a nasal, asymmetric radial pattern. Age-related thickness decline mostly occurred after the late 4th decade, described by quadratic regression models. The ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer nuclear layer + Henle’s fibre layer (ONL+HFL) were significantly associated with age (p < 0.0001 to < 0.05), demonstrating similar rates of thickness decline (mean pooled slope = − 0.07 µm/year), while the IS/OS had lesser mean pooled thickness slopes for all clusters (− 0.04 µm/year). The RNFL, OPL, and RPE exhibited no significant age-related thickness change, and the RNFL were significantly associated with sex. Analysis using spatial clusters compared to the ETDRS sectors revealed more extensive spatial definition and less variability in the former method. These spatially defined, clustered normative data and age-correction functions provide an accessible method of retinal thickness analysis with more spatial detail and less variability than the ETDRS sectors, potentially aiding the diagnosis and monitoring of retinal and optic nerve disease.
format	article
author	Matt Trinh Vincent Khou Barbara Zangerl Michael Kalloniatis Lisa Nivison-Smith
author_facet	Matt Trinh Vincent Khou Barbara Zangerl Michael Kalloniatis Lisa Nivison-Smith
author_sort	Matt Trinh
title	Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis
title_short	Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis
title_full	Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis
title_fullStr	Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis
title_full_unstemmed	Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis
title_sort	modelling normal age-related changes in individual retinal layers using location-specific oct analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0bbb1446f224ea2a479f4eed6854cdf
work_keys_str_mv	AT matttrinh modellingnormalagerelatedchangesinindividualretinallayersusinglocationspecificoctanalysis AT vincentkhou modellingnormalagerelatedchangesinindividualretinallayersusinglocationspecificoctanalysis AT barbarazangerl modellingnormalagerelatedchangesinindividualretinallayersusinglocationspecificoctanalysis AT michaelkalloniatis modellingnormalagerelatedchangesinindividualretinallayersusinglocationspecificoctanalysis AT lisanivisonsmith modellingnormalagerelatedchangesinindividualretinallayersusinglocationspecificoctanalysis
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Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis

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