FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS

Some basic parameters of immune profile have been investigated in 140 patients with chronic lymphocytic leukemia (CLL). There was shown that the cohort of CLL patients is heterogeneous for their immune profile as early as at primary diagnosis stage, showing sufficient differences in the numbers of i...

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Autores principales:	N. V. Isaeva, G. A. Zaitseva, I. A. Dokshina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	chronic lymphocytic leukemia т-lymphocytes nk-cells proportion cd4+/cd8+ Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c0bf533df9d74dc586ba10c206a69b38
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spelling	oai:doaj.org-article:c0bf533df9d74dc586ba10c206a69b382021-11-18T08:03:45ZFEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS1563-06252313-741X10.15789/1563-0625-2015-6-573-578https://doaj.org/article/c0bf533df9d74dc586ba10c206a69b382016-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/965https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSome basic parameters of immune profile have been investigated in 140 patients with chronic lymphocytic leukemia (CLL). There was shown that the cohort of CLL patients is heterogeneous for their immune profile as early as at primary diagnosis stage, showing sufficient differences in the numbers of immunocompetent cells in peripheral blood. In most cases, the interpretation of appropriate quantitative characteristics is quite difficult, if based on the conventional criteria. The numbers of activated T-lymphocytes and NK-cells were proven to be the most informative parameters of cellular immunity in this cohort. Progression of leukemic events shows a close association with only a single parameter under study, i.e., CD4+/CD8+ cell ratio.N. V. IsaevaG. A. ZaitsevaI. A. DokshinaSPb RAACIarticlechronic lymphocytic leukemiaт-lymphocytesnk-cellsproportion cd4+/cd8+Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 6, Pp 573-578 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic lymphocytic leukemia т-lymphocytes nk-cells proportion cd4+/cd8+ Immunologic diseases. Allergy RC581-607
spellingShingle	chronic lymphocytic leukemia т-lymphocytes nk-cells proportion cd4+/cd8+ Immunologic diseases. Allergy RC581-607 N. V. Isaeva G. A. Zaitseva I. A. Dokshina FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS
description	Some basic parameters of immune profile have been investigated in 140 patients with chronic lymphocytic leukemia (CLL). There was shown that the cohort of CLL patients is heterogeneous for their immune profile as early as at primary diagnosis stage, showing sufficient differences in the numbers of immunocompetent cells in peripheral blood. In most cases, the interpretation of appropriate quantitative characteristics is quite difficult, if based on the conventional criteria. The numbers of activated T-lymphocytes and NK-cells were proven to be the most informative parameters of cellular immunity in this cohort. Progression of leukemic events shows a close association with only a single parameter under study, i.e., CD4+/CD8+ cell ratio.
format	article
author	N. V. Isaeva G. A. Zaitseva I. A. Dokshina
author_facet	N. V. Isaeva G. A. Zaitseva I. A. Dokshina
author_sort	N. V. Isaeva
title	FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS
title_short	FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS
title_full	FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS
title_fullStr	FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS
title_full_unstemmed	FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS
title_sort	features of immunocompetent cells in the patients with chronic lymphocytic leukemia at primary diagnosis
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/c0bf533df9d74dc586ba10c206a69b38
work_keys_str_mv	AT nvisaeva featuresofimmunocompetentcellsinthepatientswithchroniclymphocyticleukemiaatprimarydiagnosis AT gazaitseva featuresofimmunocompetentcellsinthepatientswithchroniclymphocyticleukemiaatprimarydiagnosis AT iadokshina featuresofimmunocompetentcellsinthepatientswithchroniclymphocyticleukemiaatprimarydiagnosis
_version_	1718422444835864576

FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS

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