Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.

In this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MV...

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Autores principales:	Ibrahim Mssillou, Abdelkrim Agour, Noureddine Hamamouch, Badiaa Lyoussi, Elhoussine Derwich
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Technology T Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0c0a27c320f4f4ea081ec9db3ab0c77
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spelling	oai:doaj.org-article:c0c0a27c320f4f4ea081ec9db3ab0c772021-11-08T02:35:51ZChemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.1537-744X10.1155/2021/7011493https://doaj.org/article/c0c0a27c320f4f4ea081ec9db3ab0c772021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7011493https://doaj.org/toc/1537-744XIn this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MVE extract (98.77 ± 1.68 mg GAE/DW). The total flavonoid content was also higher in MVA extract (21.08 ± 0.38 mg QE/g DW) compared to MVE (17.65 ± 0.73 mg QE/g DW). Analysis of the chemical composition revealed the presence of 13 compounds with a total of 96.14%, with the major compound being malic acid (22.57%). Both extracts possess a good total antioxidant activity. DPPH and FRAP assays indicated that the MVE extract possesses a better antioxidant activity, with IC50 = 52.04 µg/mL ± 0.2 and EC50 of 4.51 ± 0.5 mg/mL, compared to MVA extract (IC50 = 60.57 ± 0.6 µg/mL and EC50 of 6.43 ± 0.0411 mg/mL). Moreover, both extracts exhibited strong antimicrobial activity against certain nosocomial strains as indicted by the MIC values, which ranged between 0.93 mg/mL and 10 mg/mL. Taken together, these results reveal the importance of M. vulgare as a natural antioxidant with important antimicrobial activity.Ibrahim MssillouAbdelkrim AgourNoureddine HamamouchBadiaa LyoussiElhoussine DerwichHindawi LimitedarticleTechnologyTMedicineRScienceQENThe Scientific World Journal, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Technology T Medicine R Science Q
spellingShingle	Technology T Medicine R Science Q Ibrahim Mssillou Abdelkrim Agour Noureddine Hamamouch Badiaa Lyoussi Elhoussine Derwich Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.
description	In this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MVE extract (98.77 ± 1.68 mg GAE/DW). The total flavonoid content was also higher in MVA extract (21.08 ± 0.38 mg QE/g DW) compared to MVE (17.65 ± 0.73 mg QE/g DW). Analysis of the chemical composition revealed the presence of 13 compounds with a total of 96.14%, with the major compound being malic acid (22.57%). Both extracts possess a good total antioxidant activity. DPPH and FRAP assays indicated that the MVE extract possesses a better antioxidant activity, with IC50 = 52.04 µg/mL ± 0.2 and EC50 of 4.51 ± 0.5 mg/mL, compared to MVA extract (IC50 = 60.57 ± 0.6 µg/mL and EC50 of 6.43 ± 0.0411 mg/mL). Moreover, both extracts exhibited strong antimicrobial activity against certain nosocomial strains as indicted by the MIC values, which ranged between 0.93 mg/mL and 10 mg/mL. Taken together, these results reveal the importance of M. vulgare as a natural antioxidant with important antimicrobial activity.
format	article
author	Ibrahim Mssillou Abdelkrim Agour Noureddine Hamamouch Badiaa Lyoussi Elhoussine Derwich
author_facet	Ibrahim Mssillou Abdelkrim Agour Noureddine Hamamouch Badiaa Lyoussi Elhoussine Derwich
author_sort	Ibrahim Mssillou
title	Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.
title_short	Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.
title_full	Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.
title_fullStr	Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.
title_full_unstemmed	Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.
title_sort	chemical composition and in vitro antioxidant and antimicrobial activities of marrubium vulgare l.
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/c0c0a27c320f4f4ea081ec9db3ab0c77
work_keys_str_mv	AT ibrahimmssillou chemicalcompositionandinvitroantioxidantandantimicrobialactivitiesofmarrubiumvulgarel AT abdelkrimagour chemicalcompositionandinvitroantioxidantandantimicrobialactivitiesofmarrubiumvulgarel AT noureddinehamamouch chemicalcompositionandinvitroantioxidantandantimicrobialactivitiesofmarrubiumvulgarel AT badiaalyoussi chemicalcompositionandinvitroantioxidantandantimicrobialactivitiesofmarrubiumvulgarel AT elhoussinederwich chemicalcompositionandinvitroantioxidantandantimicrobialactivitiesofmarrubiumvulgarel
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Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.

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