Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.

The manner by which axons distribute synaptic connections along dendrites remains a fundamental unresolved issue in neuronal development and physiology. We found in vitro and in vivo indications that dendrites determine the density, location and strength of their synaptic inputs by controlling the d...

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Autores principales:	Pablo Blinder, Joshua Cove, Maytal Foox, Danny Baranes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0c3e80aa1e34bf681f3c2e3d7297029
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spelling	oai:doaj.org-article:c0c3e80aa1e34bf681f3c2e3d72970292021-11-25T06:18:26ZConvergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.1932-620310.1371/journal.pone.0003782https://doaj.org/article/c0c3e80aa1e34bf681f3c2e3d72970292008-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19023423/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The manner by which axons distribute synaptic connections along dendrites remains a fundamental unresolved issue in neuronal development and physiology. We found in vitro and in vivo indications that dendrites determine the density, location and strength of their synaptic inputs by controlling the distance of their branches from those of their neighbors. Such control occurs through collective branch convergence, a behavior promoted by AMPA and NMDA glutamate receptor activity. At hubs of convergence sites, the incidence of axo-dendritic contacts as well as clustering levels, pre- and post-synaptic protein content and secretion capacity of synaptic connections are higher than found elsewhere. This coupling between synaptic distribution and the pattern of dendritic overlapping results in 'Economical Small World Network', a network configuration that enables single axons to innervate multiple and remote dendrites using short wiring lengths. Thus, activity-mediated regulation of the proximity among dendritic branches serves to pattern and strengthen neuronal connectivity.Pablo BlinderJoshua CoveMaytal FooxDanny BaranesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 11, p e3782 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pablo Blinder Joshua Cove Maytal Foox Danny Baranes Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.
description	The manner by which axons distribute synaptic connections along dendrites remains a fundamental unresolved issue in neuronal development and physiology. We found in vitro and in vivo indications that dendrites determine the density, location and strength of their synaptic inputs by controlling the distance of their branches from those of their neighbors. Such control occurs through collective branch convergence, a behavior promoted by AMPA and NMDA glutamate receptor activity. At hubs of convergence sites, the incidence of axo-dendritic contacts as well as clustering levels, pre- and post-synaptic protein content and secretion capacity of synaptic connections are higher than found elsewhere. This coupling between synaptic distribution and the pattern of dendritic overlapping results in 'Economical Small World Network', a network configuration that enables single axons to innervate multiple and remote dendrites using short wiring lengths. Thus, activity-mediated regulation of the proximity among dendritic branches serves to pattern and strengthen neuronal connectivity.
format	article
author	Pablo Blinder Joshua Cove Maytal Foox Danny Baranes
author_facet	Pablo Blinder Joshua Cove Maytal Foox Danny Baranes
author_sort	Pablo Blinder
title	Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.
title_short	Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.
title_full	Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.
title_fullStr	Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.
title_full_unstemmed	Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.
title_sort	convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/c0c3e80aa1e34bf681f3c2e3d7297029
work_keys_str_mv	AT pabloblinder convergenceamongnonsisterdendriticbranchesanactivitycontrolledmeantostrengthennetworkconnectivity AT joshuacove convergenceamongnonsisterdendriticbranchesanactivitycontrolledmeantostrengthennetworkconnectivity AT maytalfoox convergenceamongnonsisterdendriticbranchesanactivitycontrolledmeantostrengthennetworkconnectivity AT dannybaranes convergenceamongnonsisterdendriticbranchesanactivitycontrolledmeantostrengthennetworkconnectivity
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Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity.

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