Functional characterization of a bioengineered liver after heterotopic implantation in pigs

Anderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver (BEL) scaffold previously reendothelialized with HUVECs. This study constitutes an important advance in the effort to generate transplantable livers of a clinically relevant size fo...

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Autores principales: Brett D. Anderson, Erek D. Nelson, DongJin Joo, Bruce P. Amiot, Aleksandr A. Katane, Alyssa Mendenhall, Benjamin G. Steiner, Aron R. Stumbras, Victoria L. Nelson, R. Noelle Palumbo, Thomas W. Gilbert, Dominique S. Davidow, Jeffrey J. Ross, Scott L. Nyberg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c0c41e41b8204756bab603753cae52e2
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Sumario:Anderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver (BEL) scaffold previously reendothelialized with HUVECs. This study constitutes an important advance in the effort to generate transplantable livers of a clinically relevant size for humans.