L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

Filopodia have a prominent role in driving cancer cell invasion. Here, the authors show that L-type calcium channels are a druggable target regulating filopodia stability and maturation into focal adhesions in metastatic breast cancer cells.

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Autores principales:	Guillaume Jacquemet, Habib Baghirov, Maria Georgiadou, Harri Sihto, Emilia Peuhu, Pierre Cettour-Janet, Tao He, Merja Perälä, Pauliina Kronqvist, Heikki Joensuu, Johanna Ivaska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0c5390a16a0498f861b5ea72324fa6a
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spelling	oai:doaj.org-article:c0c5390a16a0498f861b5ea72324fa6a2021-12-02T16:58:23ZL-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling10.1038/ncomms132972041-1723https://doaj.org/article/c0c5390a16a0498f861b5ea72324fa6a2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13297https://doaj.org/toc/2041-1723Filopodia have a prominent role in driving cancer cell invasion. Here, the authors show that L-type calcium channels are a druggable target regulating filopodia stability and maturation into focal adhesions in metastatic breast cancer cells.Guillaume JacquemetHabib BaghirovMaria GeorgiadouHarri SihtoEmilia PeuhuPierre Cettour-JanetTao HeMerja PeräläPauliina KronqvistHeikki JoensuuJohanna IvaskaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guillaume Jacquemet Habib Baghirov Maria Georgiadou Harri Sihto Emilia Peuhu Pierre Cettour-Janet Tao He Merja Perälä Pauliina Kronqvist Heikki Joensuu Johanna Ivaska L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
description	Filopodia have a prominent role in driving cancer cell invasion. Here, the authors show that L-type calcium channels are a druggable target regulating filopodia stability and maturation into focal adhesions in metastatic breast cancer cells.
format	article
author	Guillaume Jacquemet Habib Baghirov Maria Georgiadou Harri Sihto Emilia Peuhu Pierre Cettour-Janet Tao He Merja Perälä Pauliina Kronqvist Heikki Joensuu Johanna Ivaska
author_facet	Guillaume Jacquemet Habib Baghirov Maria Georgiadou Harri Sihto Emilia Peuhu Pierre Cettour-Janet Tao He Merja Perälä Pauliina Kronqvist Heikki Joensuu Johanna Ivaska
author_sort	Guillaume Jacquemet
title	L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
title_short	L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
title_full	L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
title_fullStr	L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
title_full_unstemmed	L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
title_sort	l-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c0c5390a16a0498f861b5ea72324fa6a
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L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

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