Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature

Thermodynamic and compressibility studies together with biological studies play an important role in the effective design and development of drug. In the current study, various drug-molecular interactions have been studied from thermophysical properties. The experimental density(ρ) and speed of soun...

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Autores principales:	Ankita S. Chandak, Sangesh P. Zodape
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Metformin hydrochloride Sucrose Apparent molar volume Apparent molar compressibility Hydration number Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c0c7116eb47e49ea846598a3a6339f17
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spelling	oai:doaj.org-article:c0c7116eb47e49ea846598a3a6339f172021-11-10T04:43:46ZInsights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature2667-022410.1016/j.chphi.2021.100050https://doaj.org/article/c0c7116eb47e49ea846598a3a6339f172021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667022421000396https://doaj.org/toc/2667-0224Thermodynamic and compressibility studies together with biological studies play an important role in the effective design and development of drug. In the current study, various drug-molecular interactions have been studied from thermophysical properties. The experimental density(ρ) and speed of sound(u) measurements for anti-diabetic drug Metformin hydrochloride (M.HCl) in binary as well as in ternary mixtures have been reported within the concentration range of 0.03–0.15 mol.kg−1 at various temperatures (305.15, 310.15 and 315.15 K) and atmospheric pressure. Various parameters like apparent molar volume of solute (Vϕ) and apparent molar compressibility of solute (KS,ϕ), limiting apparent molar volume of solute (Vϕ0), limiting apparent molar compressibility of solute (KS,ϕ0) and hydration number (nh) have been measured for binary (M.HCl + water) as well as ternary (M.HCl + Sucrose + Water) systems systematically using the experimentally measured ρ and u data. Further transfer volume (ΔtrVϕ0) of M.HCl from water to aqueous sucrose solutions have been measured at different temperatures. The hydration behavior of M.HCl has been understood from the obtained values of hydration number for studied systems at various temperatures. All the experimental results have been analysed in the light of various interactions among molecules of solvent and solute respectively.Ankita S. ChandakSangesh P. ZodapeElsevierarticleMetformin hydrochlorideSucroseApparent molar volumeApparent molar compressibilityHydration numberPhysicsQC1-999ChemistryQD1-999ENChemical Physics Impact, Vol 3, Iss , Pp 100050- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metformin hydrochloride Sucrose Apparent molar volume Apparent molar compressibility Hydration number Physics QC1-999 Chemistry QD1-999
spellingShingle	Metformin hydrochloride Sucrose Apparent molar volume Apparent molar compressibility Hydration number Physics QC1-999 Chemistry QD1-999 Ankita S. Chandak Sangesh P. Zodape Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature
description	Thermodynamic and compressibility studies together with biological studies play an important role in the effective design and development of drug. In the current study, various drug-molecular interactions have been studied from thermophysical properties. The experimental density(ρ) and speed of sound(u) measurements for anti-diabetic drug Metformin hydrochloride (M.HCl) in binary as well as in ternary mixtures have been reported within the concentration range of 0.03–0.15 mol.kg−1 at various temperatures (305.15, 310.15 and 315.15 K) and atmospheric pressure. Various parameters like apparent molar volume of solute (Vϕ) and apparent molar compressibility of solute (KS,ϕ), limiting apparent molar volume of solute (Vϕ0), limiting apparent molar compressibility of solute (KS,ϕ0) and hydration number (nh) have been measured for binary (M.HCl + water) as well as ternary (M.HCl + Sucrose + Water) systems systematically using the experimentally measured ρ and u data. Further transfer volume (ΔtrVϕ0) of M.HCl from water to aqueous sucrose solutions have been measured at different temperatures. The hydration behavior of M.HCl has been understood from the obtained values of hydration number for studied systems at various temperatures. All the experimental results have been analysed in the light of various interactions among molecules of solvent and solute respectively.
format	article
author	Ankita S. Chandak Sangesh P. Zodape
author_facet	Ankita S. Chandak Sangesh P. Zodape
author_sort	Ankita S. Chandak
title	Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature
title_short	Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature
title_full	Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature
title_fullStr	Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature
title_full_unstemmed	Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature
title_sort	insights into the temperature and concentration dependent studies of the anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c0c7116eb47e49ea846598a3a6339f17
work_keys_str_mv	AT ankitaschandak insightsintothetemperatureandconcentrationdependentstudiesoftheantidiabeticdruginaqueousbinaryandternarywatersucrosemixturesatbodytemperature AT sangeshpzodape insightsintothetemperatureandconcentrationdependentstudiesoftheantidiabeticdruginaqueousbinaryandternarywatersucrosemixturesatbodytemperature
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Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature

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