Osteosarcopenia in chronic pancreatitis

Aim. To determine clinical features and some mechanisms of osteosarcopenia development in patients with chronic pancreatitis (CP). Materials and methods. A casecontrol study was conducted on the basis of the Saratov State Clinical Hospital 5 in 20152018 of patients with CP. In a study of 161 pati...

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Autores principales:	Irina V. Kozlova, Anna P. Bykova
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	chronic pancreatitis sarcopenia osteopenia colon cytokines Medicine R
Acceso en línea:	https://doaj.org/article/c0c9aa715a184a418e349befc869264a
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spelling	oai:doaj.org-article:c0c9aa715a184a418e349befc869264a2021-12-01T12:22:36ZOsteosarcopenia in chronic pancreatitis0040-36602309-534210.26442/00403660.2021.08.200971https://doaj.org/article/c0c9aa715a184a418e349befc869264a2021-08-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/79417/60066https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342Aim. To determine clinical features and some mechanisms of osteosarcopenia development in patients with chronic pancreatitis (CP). Materials and methods. A casecontrol study was conducted on the basis of the Saratov State Clinical Hospital 5 in 20152018 of patients with CP. In a study of 161 patients with CP included, the control group 30 healthy individuals. Patients were divided into groups according to the etiology of CP: 79 with toxic-metabolic CP, 82 with biliary CP. To determine the risks of low-energy fractures, 154 patients were tested with the Fracture risk assessment tool (FRAX). Along with the standard examination, 30 patients with CP dual-energy X-ray absorptiometry was performed. To assess the state of skeletal muscles, body mass index was determined, hand-held dynamometry was performed, and a set of Short Physical Performance Battery (SPPB) tests was used. Along with the assessment of traditional risk factors for osteosarcopenia gender, age, state of reproductive function in women, body mass index, functional state of the pancreas (pancreas) the quantitative content of interleukins (IL)-2, 6, 8 in in colonic biopsies was analyzed by enzyme-linked immunosorbent assay (ELISA). Results. Bone disorders, according to densitometry, was detected in 70.0% of patients with CP, in 13.3% of the control group. Presarcopenia was detected in 62 (38.5%) patients with CP, sarcopenia in 34 (21.1%), in the control group presarcopenia and sarcopenia were not detected. Sarcopenia was statistically significantly more common in toxic-metabolic CP than in biliary CP (2=11.6; p0.001). Correlations of the lumbar spine T-score and IL-6 (r=-0.29; p=0.03), IL-8 (r=-0.29; p=0.04) were revealed. Correlations between sarcopenia and the concentration of cytokines in the in the colon mucosa in CP were determined (IL-2: r=0.44; p0.001; IL-6: r=0.48; p0.001; IL-8: r=0.42; p0.001). Conclusion. The development of osteopenia and sarcopenia syndromes in CP is interrelated and associated with both traditional risk factors and an increased concentration of cytokines in the in the colon mucosa.Irina V. KozlovaAnna P. Bykova"Consilium Medicum" Publishing housearticlechronic pancreatitissarcopeniaosteopeniacoloncytokinesMedicineRRUТерапевтический архив, Vol 93, Iss 8, Pp 869-875 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic pancreatitis sarcopenia osteopenia colon cytokines Medicine R
spellingShingle	chronic pancreatitis sarcopenia osteopenia colon cytokines Medicine R Irina V. Kozlova Anna P. Bykova Osteosarcopenia in chronic pancreatitis
description	Aim. To determine clinical features and some mechanisms of osteosarcopenia development in patients with chronic pancreatitis (CP). Materials and methods. A casecontrol study was conducted on the basis of the Saratov State Clinical Hospital 5 in 20152018 of patients with CP. In a study of 161 patients with CP included, the control group 30 healthy individuals. Patients were divided into groups according to the etiology of CP: 79 with toxic-metabolic CP, 82 with biliary CP. To determine the risks of low-energy fractures, 154 patients were tested with the Fracture risk assessment tool (FRAX). Along with the standard examination, 30 patients with CP dual-energy X-ray absorptiometry was performed. To assess the state of skeletal muscles, body mass index was determined, hand-held dynamometry was performed, and a set of Short Physical Performance Battery (SPPB) tests was used. Along with the assessment of traditional risk factors for osteosarcopenia gender, age, state of reproductive function in women, body mass index, functional state of the pancreas (pancreas) the quantitative content of interleukins (IL)-2, 6, 8 in in colonic biopsies was analyzed by enzyme-linked immunosorbent assay (ELISA). Results. Bone disorders, according to densitometry, was detected in 70.0% of patients with CP, in 13.3% of the control group. Presarcopenia was detected in 62 (38.5%) patients with CP, sarcopenia in 34 (21.1%), in the control group presarcopenia and sarcopenia were not detected. Sarcopenia was statistically significantly more common in toxic-metabolic CP than in biliary CP (2=11.6; p0.001). Correlations of the lumbar spine T-score and IL-6 (r=-0.29; p=0.03), IL-8 (r=-0.29; p=0.04) were revealed. Correlations between sarcopenia and the concentration of cytokines in the in the colon mucosa in CP were determined (IL-2: r=0.44; p0.001; IL-6: r=0.48; p0.001; IL-8: r=0.42; p0.001). Conclusion. The development of osteopenia and sarcopenia syndromes in CP is interrelated and associated with both traditional risk factors and an increased concentration of cytokines in the in the colon mucosa.
format	article
author	Irina V. Kozlova Anna P. Bykova
author_facet	Irina V. Kozlova Anna P. Bykova
author_sort	Irina V. Kozlova
title	Osteosarcopenia in chronic pancreatitis
title_short	Osteosarcopenia in chronic pancreatitis
title_full	Osteosarcopenia in chronic pancreatitis
title_fullStr	Osteosarcopenia in chronic pancreatitis
title_full_unstemmed	Osteosarcopenia in chronic pancreatitis
title_sort	osteosarcopenia in chronic pancreatitis
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/c0c9aa715a184a418e349befc869264a
work_keys_str_mv	AT irinavkozlova osteosarcopeniainchronicpancreatitis AT annapbykova osteosarcopeniainchronicpancreatitis
_version_	1718405199001812992

Osteosarcopenia in chronic pancreatitis

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