Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.

The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanogaster eye, the Hippo pathway controls the fate choice between one of two subtypes that express either the blue light-sensitive Rhodopsin 5 (Hippo inactive R8 subtype) or...

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Autores principales:	Jonathan M Pojer, Abdul Jabbar Saiful Hilmi, Shu Kondo, Kieran F Harvey
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/c0c9fe18edd2412f95b842b832ce0cb0
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spelling	oai:doaj.org-article:c0c9fe18edd2412f95b842b832ce0cb02021-12-02T20:02:42ZCrumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.1553-73901553-740410.1371/journal.pgen.1009146https://doaj.org/article/c0c9fe18edd2412f95b842b832ce0cb02021-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009146https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanogaster eye, the Hippo pathway controls the fate choice between one of two subtypes that express either the blue light-sensitive Rhodopsin 5 (Hippo inactive R8 subtype) or the green light-sensitive Rhodopsin 6 (Hippo active R8 subtype). The degree to which the mechanism of Hippo signal transduction and the proteins that mediate it are conserved in organ growth and R8 cell fate choice is currently unclear. Here, we identify Crumbs and the apical spectrin cytoskeleton as regulators of R8 cell fate. By contrast, other proteins that influence Hippo-dependent organ growth, such as the basolateral spectrin cytoskeleton and Ajuba, are dispensable for the R8 cell fate choice. Surprisingly, Crumbs promotes the Rhodopsin 5 cell fate, which is driven by Yorkie, rather than the Rhodopsin 6 cell fate, which is driven by Warts and the Hippo pathway, which contrasts with its impact on Hippo activity in organ growth. Furthermore, neither the apical spectrin cytoskeleton nor Crumbs appear to regulate the Hippo pathway through mechanisms that have been observed in growing organs. Together, these results show that only a subset of Hippo pathway proteins regulate the R8 binary cell fate decision and that aspects of Hippo signalling differ between growing organs and post-mitotic R8 cells.Jonathan M PojerAbdul Jabbar Saiful HilmiShu KondoKieran F HarveyPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 6, p e1009146 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Jonathan M Pojer Abdul Jabbar Saiful Hilmi Shu Kondo Kieran F Harvey Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
description	The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanogaster eye, the Hippo pathway controls the fate choice between one of two subtypes that express either the blue light-sensitive Rhodopsin 5 (Hippo inactive R8 subtype) or the green light-sensitive Rhodopsin 6 (Hippo active R8 subtype). The degree to which the mechanism of Hippo signal transduction and the proteins that mediate it are conserved in organ growth and R8 cell fate choice is currently unclear. Here, we identify Crumbs and the apical spectrin cytoskeleton as regulators of R8 cell fate. By contrast, other proteins that influence Hippo-dependent organ growth, such as the basolateral spectrin cytoskeleton and Ajuba, are dispensable for the R8 cell fate choice. Surprisingly, Crumbs promotes the Rhodopsin 5 cell fate, which is driven by Yorkie, rather than the Rhodopsin 6 cell fate, which is driven by Warts and the Hippo pathway, which contrasts with its impact on Hippo activity in organ growth. Furthermore, neither the apical spectrin cytoskeleton nor Crumbs appear to regulate the Hippo pathway through mechanisms that have been observed in growing organs. Together, these results show that only a subset of Hippo pathway proteins regulate the R8 binary cell fate decision and that aspects of Hippo signalling differ between growing organs and post-mitotic R8 cells.
format	article
author	Jonathan M Pojer Abdul Jabbar Saiful Hilmi Shu Kondo Kieran F Harvey
author_facet	Jonathan M Pojer Abdul Jabbar Saiful Hilmi Shu Kondo Kieran F Harvey
author_sort	Jonathan M Pojer
title	Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
title_short	Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
title_full	Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
title_fullStr	Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
title_full_unstemmed	Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
title_sort	crumbs and the apical spectrin cytoskeleton regulate r8 cell fate in the drosophila eye.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c0c9fe18edd2412f95b842b832ce0cb0
work_keys_str_mv	AT jonathanmpojer crumbsandtheapicalspectrincytoskeletonregulater8cellfateinthedrosophilaeye AT abduljabbarsaifulhilmi crumbsandtheapicalspectrincytoskeletonregulater8cellfateinthedrosophilaeye AT shukondo crumbsandtheapicalspectrincytoskeletonregulater8cellfateinthedrosophilaeye AT kieranfharvey crumbsandtheapicalspectrincytoskeletonregulater8cellfateinthedrosophilaeye
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Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.

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