The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin

The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin

RepID has previously been shown to promote origin firing. Here the authors reveal that RepID regulates replication origins via the recruitment of the CRL4 complex, and prevents re-initiation and unscheduled DNA replication.

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Autores principales: Sang-Min Jang, Ya Zhang, Koichi Utani, Haiqing Fu, Christophe E. Redon, Anna B. Marks, Owen K. Smith, Catherine J. Redmond, Adrian M. Baris, Danielle A. Tulchinsky, Mirit I. Aladjem
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/c0caf93747014adfa69d1bd61d2bb88a
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