In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker

In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker

Abstract Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by silencing of the Fragile X Mental Retardation (FMR1) gene. The resulting loss of Fragile X Mental Retardation Protein (FMRP) leads to excessive glutamate signaling via metabotropic glutamate subtype 5 receptors (mGluR5) whi...

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Autores principales: Maria Mody, Yoann Petibon, Paul Han, Darshini Kuruppu, Chao Ma, Daniel Yokell, Ramesh Neelamegam, Marc D. Normandin, Georges El Fakhri, Anna-Liisa Brownell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/c0ce7b7ae80f45c585088156fbb40608
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