USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin

Axin is a scaffolding protein known for its role in Wnt signalling that can be marked with a variety of post-translational modifications. Here, Cong et al. demonstrate that USP7 de-ubiquinates Axin and that canonical Wnt signaling output can be increased with USP7 inhibitors.

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Autores principales:	Lei Ji, Bo Lu, Raffaella Zamponi, Olga Charlat, Robert Aversa, Zinger Yang, Frederic Sigoillot, Xiaoping Zhu, Tiancen Hu, John S. Reece-Hoyes, Carsten Russ, Gregory Michaud, Jan S. Tchorz, Xiaomo Jiang, Feng Cong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0ce8720c63e468a9e5f72379fe211b1
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spelling	oai:doaj.org-article:c0ce8720c63e468a9e5f72379fe211b12021-12-02T16:51:01ZUSP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin10.1038/s41467-019-12143-32041-1723https://doaj.org/article/c0ce8720c63e468a9e5f72379fe211b12019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12143-3https://doaj.org/toc/2041-1723Axin is a scaffolding protein known for its role in Wnt signalling that can be marked with a variety of post-translational modifications. Here, Cong et al. demonstrate that USP7 de-ubiquinates Axin and that canonical Wnt signaling output can be increased with USP7 inhibitors.Lei JiBo LuRaffaella ZamponiOlga CharlatRobert AversaZinger YangFrederic SigoillotXiaoping ZhuTiancen HuJohn S. Reece-HoyesCarsten RussGregory MichaudJan S. TchorzXiaomo JiangFeng CongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Ji Bo Lu Raffaella Zamponi Olga Charlat Robert Aversa Zinger Yang Frederic Sigoillot Xiaoping Zhu Tiancen Hu John S. Reece-Hoyes Carsten Russ Gregory Michaud Jan S. Tchorz Xiaomo Jiang Feng Cong USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
description	Axin is a scaffolding protein known for its role in Wnt signalling that can be marked with a variety of post-translational modifications. Here, Cong et al. demonstrate that USP7 de-ubiquinates Axin and that canonical Wnt signaling output can be increased with USP7 inhibitors.
format	article
author	Lei Ji Bo Lu Raffaella Zamponi Olga Charlat Robert Aversa Zinger Yang Frederic Sigoillot Xiaoping Zhu Tiancen Hu John S. Reece-Hoyes Carsten Russ Gregory Michaud Jan S. Tchorz Xiaomo Jiang Feng Cong
author_facet	Lei Ji Bo Lu Raffaella Zamponi Olga Charlat Robert Aversa Zinger Yang Frederic Sigoillot Xiaoping Zhu Tiancen Hu John S. Reece-Hoyes Carsten Russ Gregory Michaud Jan S. Tchorz Xiaomo Jiang Feng Cong
author_sort	Lei Ji
title	USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
title_short	USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
title_full	USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
title_fullStr	USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
title_full_unstemmed	USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
title_sort	usp7 inhibits wnt/β-catenin signaling through promoting stabilization of axin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c0ce8720c63e468a9e5f72379fe211b1
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USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin

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