ABCG2 transports anticancer drugs via a closed-to-open switch

ABCG2 is a human ABC transporter that actively extrudes a wide variety of compounds from cells but the mechanisms of multidrug transport remain obscure. Here authors present cryo-EM structures of ABCG2 in the apo state, and bound to the three structurally distinct chemotherapeutics and demonstrate h...

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Autores principales:	Benjamin J. Orlando, Maofu Liao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0cfdf397d3448be829b243862bb14fc
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spelling	oai:doaj.org-article:c0cfdf397d3448be829b243862bb14fc2021-12-02T14:42:48ZABCG2 transports anticancer drugs via a closed-to-open switch10.1038/s41467-020-16155-22041-1723https://doaj.org/article/c0cfdf397d3448be829b243862bb14fc2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16155-2https://doaj.org/toc/2041-1723ABCG2 is a human ABC transporter that actively extrudes a wide variety of compounds from cells but the mechanisms of multidrug transport remain obscure. Here authors present cryo-EM structures of ABCG2 in the apo state, and bound to the three structurally distinct chemotherapeutics and demonstrate how these molecules open the closed conformation of the transporter.Benjamin J. OrlandoMaofu LiaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin J. Orlando Maofu Liao ABCG2 transports anticancer drugs via a closed-to-open switch
description	ABCG2 is a human ABC transporter that actively extrudes a wide variety of compounds from cells but the mechanisms of multidrug transport remain obscure. Here authors present cryo-EM structures of ABCG2 in the apo state, and bound to the three structurally distinct chemotherapeutics and demonstrate how these molecules open the closed conformation of the transporter.
format	article
author	Benjamin J. Orlando Maofu Liao
author_facet	Benjamin J. Orlando Maofu Liao
author_sort	Benjamin J. Orlando
title	ABCG2 transports anticancer drugs via a closed-to-open switch
title_short	ABCG2 transports anticancer drugs via a closed-to-open switch
title_full	ABCG2 transports anticancer drugs via a closed-to-open switch
title_fullStr	ABCG2 transports anticancer drugs via a closed-to-open switch
title_full_unstemmed	ABCG2 transports anticancer drugs via a closed-to-open switch
title_sort	abcg2 transports anticancer drugs via a closed-to-open switch
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c0cfdf397d3448be829b243862bb14fc
work_keys_str_mv	AT benjaminjorlando abcg2transportsanticancerdrugsviaaclosedtoopenswitch AT maofuliao abcg2transportsanticancerdrugsviaaclosedtoopenswitch
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ABCG2 transports anticancer drugs via a closed-to-open switch

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